Affiliation:
1. Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Abstract
Cancer is the leading cause of death in both humans and companion animals. Long non-coding RNA (lncRNA) plays a crucial role in the progression of various types of cancers in humans, involving tumor proliferation, metastasis, angiogenesis, and signaling pathways, and acts as a potential biomarker for diagnosis and targeted treatment. However, research on lncRNAs related to canine tumors is in an early stage. Dogs have long been considered a promising natural model for human disease. This article summarizes the molecular function of lncRNAs as novel biomarkers in various types of canine tumors, providing new insights into canine tumor diagnosis and treatment. Further research on the function and mechanism of lncRNAs is needed, which will benefit both human and veterinary medicine.
Funder
National Natural Science Foundation of China
Research Fund (Clinical Diagnosis and Treatment of Pet) for Young College Teachers in Ruipeng Commonweal Foundation
Innovation Training Program for College Students of Fujian Province
Reference52 articles.
1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries;Sung;CA Cancer J. Clin.,2021
2. Vail, D.M., Thamm, D.H., and Liptak, J.M. (2020). Withrow and MacEwen’s Small Animal Clinical Oncology, Elsevier.
3. Domestic Dogs and Cancer Research: A Breed-Based Genomics Approach;Davis;ILAR J.,2014
4. Mukherjee, S. (2011). The Emperor of All Maladies: A biography of Cancer, Scribner.
5. Comparative oncology: Overcoming human cancer through companion animal studies;Oh;Exp. Mol. Med.,2023