The Prognostic Role of Preoperative Hematological and Inflammatory Indices in Canine Appendicular Osteosarcoma

Author:

Rigas Konstantinos12,Tanis Jean-Benoit13ORCID,Morello Emanuela4ORCID,Polton Gerry5,Marconato Laura6ORCID,Carroll Marlon4ORCID,Ciriano Cerda EstelLa7,Ramos Sofia5,Baker Charlotte1,Finotello Riccardo18ORCID

Affiliation:

1. Department of Small Animal Clinical Sciences, Institute of Veterinary Science, University of Liverpool, Neston CH64 7TE, UK

2. Southfields Veterinary Specialists, Basildon SS14 3AP, UK

3. Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L7 8TX, UK

4. Department of Veterinary Sciences, University of Turin, 10095 Grugliasco, Italy

5. North Downs Specialist Referrals, Bletchingley RH1 4QP, UK

6. Department of Veterinary Medical Sciences, University of Bologna, 40126 Bologna, Italy

7. Northwest Veterinary Specialists, Runcorn WA7 3FW, UK

8. Department of Veterinary Medicine, University of Bari, 70010 Valenzano, Italy

Abstract

Hematological indices play a prognostic role in human osteosarcoma (OSA), but data are limited in dogs. The aim of this retrospective multicentric cohort study was to investigate the prognostic significance of pre-operative hematological/inflammatory indices in a cohort of client-owned dogs with appendicular OSA receiving standardized treatment. Cut-offs associated with progression-free survival (PFS) for pre-operative hematological values/ratios were established using the minimal p-value approach. Historical prognostic factors were also assessed. Statistical analyses were performed for the whole population and after the exclusion of sighthounds. Fifty-nine dogs were included (13 were sighthounds). Multivariable analysis revealed that a low neutrophil count (<4.37 × 109/L, HR0.28, CI 95% 0.13–0.61, p = 0.001), a high red blood cell count (≥7.91, HR3.5, CI 95% 1.56–7.9, p = 0.002), and a proximal humerus location (HR3.0, CI 95% 1.48–6.1, p = 0.002) were associated with shorter PFS. In the sighthound-only population, only OSA location was significantly associated with PFS in univariable analysis. When sighthounds were excluded, a low neutrophil count, a low monocyte count, and a proximal humerus location were associated with shorter PFS, in multivariable analysis. Neutrophil count and possibly monocyte and red blood cell counts can be useful prognostic markers in canine OSA treated with amputation and adjuvant carboplatin. However, not all indices are appropriate in sighthounds.

Publisher

MDPI AG

Subject

General Veterinary

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