Effects of New Mutations in BMPRIB, GDF9, BMP15, LEPR, and B4GALNT2 Genes on Litter Size in Sheep
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Published:2023-03-28
Issue:4
Volume:10
Page:258
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ISSN:2306-7381
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Container-title:Veterinary Sciences
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language:en
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Short-container-title:Veterinary Sciences
Author:
Ji Xuewen1, Cao Ziwei2, Hao Qi1, He Mei2, Cang Ming1, Yu Haiquan1, Ma Qing3, Li Xihe1ORCID, Bao Siqin1ORCID, Wang Jianguo1, Tong Bin1ORCID
Affiliation:
1. The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010070, China 2. Xilingol Mengzhiyuan Animal Husbandry Company, Xilingol 026000, China 3. Institute of Animal Sciences, Ningxia Academy of Agricultural and Forestry Sciences, Yinchuan 750001, China
Abstract
Prolificacy is a crucial characteristic of livestock, particularly for species such as sheep that have many births. The objectives of this study were as follows: (1) to investigate the genetic diversity of the 13 new and 7 known variants in the BMPRIB, GDF9, BMP15, LEPR, and B4GALNT2 genes in Ujimqin (UM), the F1 population of Dorper × Ujimqin crossbred (DPU), the F1 population of Suffolk × Ujimqin crossbred (SFKU), Sonid sheep (SN), Tan sheep (Tan), Hu sheep (Hu), and Small-tailed Han sheep (STH) sheep breeds/populations; (2) to perform an association analysis of the above 20 variants with litter size in 325 UM, 304 DPU, and 66 SFKU sheep populations; (3) to compare the frequencies of the litter-size-related alleles of these 20 variants among 8 sheep breeds/populations (the above seven sheep breeds + Mongolia sheep breed). With the use of the Sequenom MassARRAY®SNP assay technology, these 20 mutations were genotyped. The association analysis results showed that the c.746A>G (FecB) mutation in BMPR1B was significantly associated with the litter size of UM and DPU, the c.994A>G (FecGA) in GDF9 was significantly associated with the litter size of SFKU, and the c.31_33CTTinsdel (B1) in BMP15 was significantly associated with the litter size of UM. Our findings might provide valuable genetic markers for expanding sheep litter sizes.
Funder
Inner Mongolia Science and Technology Plan Xilingol Science and Technology Plan State Key Laboratory for Reproductive Regulation and Breeding of Grassland Livestock “Grassland Talents” Scholars Program Inner Mongolia University Ministry of Human Resources and Social Security, China “Tan sheep line breeding” of the Ningxia Hui Autonomous Region
Subject
General Veterinary
Reference38 articles.
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