Research Progress on NSP11 of Porcine Reproductive and Respiratory Syndrome Virus-Reference-Cited by-同舟云学术

Research Progress on NSP11 of Porcine Reproductive and Respiratory Syndrome Virus

Published:2023-07-10 Issue:7 Volume:10 Page:451
ISSN:2306-7381
Container-title:Veterinary Sciences
language:en
Short-container-title:Veterinary Sciences

Author:

Zheng Yajie¹,Zhang Hang¹,Luo Qin¹,Sha Huiyang¹,Li Gan¹,Mu Xuanru¹,He Yingxin¹,Kong Weili²^ORCID,Wu Anfeng³,Zhang Haoji¹,Yu Xingang¹

Affiliation:

1. School of Life Science and Engineering, Foshan University, Foshan 528231, China

2. Gladstone Institutes of Virology and Immunology, University of California, San Francisco, CA 94158, USA

3. Maccura Biotechnology Co., Ltd., Chengdu 510000, China

Abstract

Porcine reproductive and respiratory syndrome (PRRS) is a virulent infectious disease caused by the PRRS virus (PRRSV). The non-structural protein 11 (NSP11) of PRRSV is a nidovirus-specific endonuclease (NendoU), which displays uridine specificity and catalytic functions conserved throughout the entire NendoU family and exerts a wide range of biological effects. This review discusses the genetic evolution of NSP11, its effects on PRRSV replication and virulence, its interaction with other PRRSV and host proteins, its regulation of host immunity, the conserved characteristics of its enzyme activity (NendoU), and its diagnosis, providing an essential theoretical basis for in-depth studies of PRRSV pathogenesis and vaccine design.

Funder

National Natural Science Foundation of China

Guangdong Basic and Applied Basic Research Foundation

Publisher

MDPI AG

Subject

General Veterinary

Link

https://www.mdpi.com/2306-7381/10/7/451/pdf

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