Cuttlefish Bone-Derived Calcium Phosphate Bioceramics Have Enhanced Osteogenic Properties
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Published:2024-07-29
Issue:8
Volume:15
Page:212
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ISSN:2079-4983
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Container-title:Journal of Functional Biomaterials
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language:en
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Short-container-title:JFB
Author:
Pang Boqi12, Xian Jiaru12, Chen Jiajun1, Ng Liqi2, Li Mengting1ORCID, Zhao Guangchun1, E Yixun1, Wang Xiaorui1, Cao Xiaxin1, Zhang Changze1, Zhang Mingjing2ORCID, Liu Chaozong12ORCID
Affiliation:
1. Hainan Provincial Fine Chemical Engineering Research Center, Hainan University, Haikou 570228, China 2. Institute of Orthopaedic & Musculoskeletal Science, University College London, Royal National Orthopaedic Hospital, London HA7 4LP, UK
Abstract
Cuttlefish bones are byproducts of cuttlefish processing and are readily available in the marine food industry. In this study, calcium phosphate bioceramics were prepared from cuttlefish bones using a two-stage hydrothermal calcination process. The results indicated that all bioceramics derived from cuttlefish bones had a higher degradation capacity, better bone-like apatite formation ability, and higher degree of osteogenic differentiation than commercially available hydroxyapatite. Notably, β-tricalcium phosphate, which had the highest degree of Ca2+ and Sr2+ dissolution among the bioceramics extracted, can significantly upregulate osteogenic markers (alkaline phosphatase, osteocalcin) and stimulate bone matrix mineralization. Thus, it is a promising bioceramic material for applications in bone regeneration.
Funder
International Science & Technology Cooperation Program of Hainan Province Engineering and Physical Sciences Research Council via DTP CASE Programme Medical Research Council through MRC-UCL Therapeutic Acceleration Support (TAS) Fund National Institute for Health and Care Research through UCLH BRC-UCL Therapeutic Acceleration Support (TAS) Fund
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