The Effects of Exercise during Pregnancy on Gestational Diabetes Mellitus, Preeclampsia, and Spontaneous Abortion among Healthy Women—A Systematic Review and Meta-Analysis-Reference-Cited by-同舟云学术

The Effects of Exercise during Pregnancy on Gestational Diabetes Mellitus, Preeclampsia, and Spontaneous Abortion among Healthy Women—A Systematic Review and Meta-Analysis

Published:2023-06-06 Issue:12 Volume:20 Page:6069
ISSN:1660-4601
Container-title:International Journal of Environmental Research and Public Health
language:en
Short-container-title:IJERPH

Author:

Paulsen Camilla Paludan¹,Bandak Elisabeth²³^ORCID,Edemann-Callesen Henriette⁴^ORCID,Juhl Carsten Bogh¹⁵^ORCID,Händel Mina Nicole²⁶^ORCID

Affiliation:

1. Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, 5230 Odense, Denmark

2. The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark

3. Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark

4. Metodekonsulent Callesen, 8600 Silkeborg, Denmark

5. Department Physiotherapy and Occupational Therapy, Copenhagen University Hospital, Herlev and Gentofte, 2100 Copenhagen, Denmark

6. Research Unit OPEN, Department of Clinical Research, University of Southern Denmark, 5230 Odense, Denmark

Abstract

The aim was to compare the effects of different exercise modalities (aerobic, resistance, aerobic and resistance combined, or mind–body exercise) on gestational diabetes mellitus (GDM), preeclampsia, spontaneous abortion, withdrawal from the study, and adverse events in healthy pregnant women. A systematic search was conducted in February 2022 using MEDLINE, EMBASE, Cochrane library, and SPORT Discus to identify eligible randomized trials. The meta-analysis of 18 studies that examined exercise compared to no exercise showed a reduced risk of GDM (RR: 0.66 (95% CI: 0.50 to 0.86)). No subgroup differences were found regarding modality, intensity, or supervision. Exercise did not reduce the risk of preeclampsia (nine studies, RR: 0.65 (95% CI: 0.42 to 1.03)); however, in subgroup analyses, mind–body exercise and low-intensity exercise seemed to be effective in reduction of preeclampsia. There was no effect of exercise on withdrawal or adverse events found. No studies reported on spontaneous abortion, therefore, exercise during pregnancy is beneficial and safe. In the prevention of GDM, any modality and intensity seem equally effective. Subgroup analyses support an association between mind–body exercise and physical activity with low intensity and reduced risk of preeclampsia, but more high-quality randomized studies are needed. PROSPERO: CRD42022307053.

Funder

Oak Foundation

Publisher

MDPI AG

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

Link

https://www.mdpi.com/1660-4601/20/12/6069/pdf

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