The Relationship of Left Ventricular Diastolic Dysfunction and Asymmetrical Dimethylarginine as a Biomarker of Endothelial Dysfunction with Cardiovascular Risk Assessed by Systematic Coronary Risk Evaluation2 Algorithm and Heart Failure—A Cross-Sectional Study

Author:

Sušić Livija12ORCID,Maričić Lana23ORCID,Šahinović Ines24ORCID,Kralik Kristina2ORCID,Klobučar Lucija23ORCID,Ćosić Mateja1ORCID,Sušić Tihomir5ORCID,Vincelj Josip26ORCID,Burić Antonio7ORCID,Burić Marko2ORCID,Lukić Matea2ORCID

Affiliation:

1. Department of Specialist-Consultative Health Care, Health Center of Osijek-Baranja County, 31000 Osijek, Croatia

2. Faculty of Medicine, University “Josip Juraj Strossmayer”, 31000 Osijek, Croatia

3. Department of Cardiology, University Hospital Center Osijek, 31000 Osijek, Croatia

4. Department of Clinical Laboratory Diagnostics, University Hospital Center Osijek, 31000 Osijek, Croatia

5. The Information Institute Osijek, 31000 Osijek, Croatia

6. NovaMed Health Center Zagreb, 10000 Zagreb, Croatia

7. Department of Radiology, Health Center of Osijek-Baranja County, 31000 Osijek, Croatia

Abstract

Background: Cardiovascular (CV) risk factors, causing endothelial dysfunction (ED) and left ventricular diastolic dysfunction (LVDD), contribute to an increased risk of heart failure (HF). The aim of this study was to determine the relationship between the occurrence of LVDD and ED with CV risk assessed by the Systematic Coronary Risk Evaluation2 (SCORE2) algorithm and HF. Methods: In the period from November 2019 to May 2022, a cross-sectional study that included 178 middle-aged adults was conducted. Transthoracic echocardiography (TTE) was used to assess left ventricular (LV) diastolic and systolic function. ED was assessed using the plasma values of asymmetric dimethylarginine (ADMA) and was determined using the ELISA method. Results: The majority of subjects with LVDD grades 2 and 3 had high/very high SCORE2, developed HF and all were taking medication (p < 0.001). They also had significantly lowest plasma ADMA values (p < 0.001). We found that the reduction of ADMA concentration is influenced by certain groups of drugs, or more significantly, by their combinations (p < 0.001). Conclusions: In our study, we confirmed a positive correlation between LVDD, HF and SCORE2 severity. The results showed a negative correlation between the biomarkers of ED, LVDD severity, HF, and SCORE2, which we believe is due to medication effects.

Publisher

MDPI AG

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

Reference65 articles.

1. World Health Organization (2023, February 03). Cardiovascular Diseases. Available online: https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds).

2. Global Burden of Ischemic Heart Disease and Attributable Risk Factors, 1990–2017: A Secondary Analysis Based on the Global Burden of Disease Study 2017;Wang;Clin. Epidemiol.,2021

3. Burden of heart failure and underlying causes in 195 countries and territories from 1990 to 2017;Bragazzi;Eur. J. Prev. Cardiol.,2021

4. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure;McDonagh;Eur. Heart J.,2021

5. Left Ventricular Diastolic Function in Hypertension: Methodological Considerations and Clinical Implications;Palmiero;J. Clin. Med. Res.,2015

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