Association between Muscle Fatigability, Self-Perceived Fatigue and C-Reactive Protein at Admission in Hospitalized Geriatric Patients

Author:

Hoekstra Carmen1,Swart Myrthe1ORCID,Bautmans Ivan234ORCID,Melis René1,Peeters Geeske1

Affiliation:

1. Department of Geriatric Medicine, Radboud University Medical Centre, Geert Grooteplein Zuid 10 (Route 696), Postbus 9101, 6500 HB Nijmegen, The Netherlands

2. Gerontology Department, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, 1090 Brussels, Belgium

3. Frailty in Ageing Research (FRIA) Group, Vrije Universiteit Brussel, 1090 Brussels, Belgium

4. Department of Geriatrics, Universitair Ziekenhuis Brussel, 1090 Brussels, Belgium

Abstract

Background: The capacity to perceived vitality (CPV) ratio is a novel measure for intrinsic capacity or resilience based on grip work and self-perceived fatigue. CPV has been associated with pre-frailty in older adults and post-surgery inflammation in adults. To better understand the utility of this measure in a frail population, we examined the association between CPV and inflammation in geriatric inpatients. Methods: Data were obtained from 104 hospitalized geriatric patients. The average age of participants was 83.3 ± 7.5 years, and 55.8% of participants were women. In the cross-sectional analyses, associations between C-reactive protein (CRP), grip work (GW), self-perceived fatigue (SPF) and the CPV ratio (higher values indicate better capacity) were examined using linear regression adjusted for confounders. Results: The adjusted association between CRP (abnormal vs. normal) and the CPV ratio was not statistically significant (B = −0.33, 95% CI = −4.00 to 3.34). Associations between CRP and GW (B = 25.53, 95% CI = −478.23 to 529.30) and SPF (B = 0.57, 95% CI = −0.64 to 1.77) were also not statistically significant. Similar results were found in unadjusted models and analyses of cases with complete data. Conclusions: In this frail group of geriatric inpatients, inflammation, routinely assessed with CRP, was not associated with CPV or its components, GW and SPF. Further research is needed to explore whether CPV is a useful indicator of frailty or recovery capacity in hospitalized geriatric patients.

Funder

EU

INNOVIRIS

VLAIO

ZonMW

Publisher

MDPI AG

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

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