Abstract
The faecal immunochemical test (FIT) has been increasingly used for organised colorectal cancer (CRC) screening. We assessed the impact of a six-year existing FIT screening programme in Flanders (Belgium) on CRC incidence, mortality and survival. The Flemish CRC screening programme started in 2013, targeting individuals aged 50–74 years. Joinpoint regression was used to investigate trends of age-standardised CRC incidence and mortality among individuals aged 50–79 years (2004–2019). Their 5-year relative survival was calculated using the Ederer II method. We found that FIT screening significantly reduced CRC incidence, especially that of advanced-stage CRCs (69.8/100,000 in 2012 vs. 51.1/100,000 in 2019), with a greater impact in men. Mortality started to decline in men two years after organised screening implementation (annual reduction of 9.3% after 2015 vs. 2.2% before 2015). The 5-year relative survival was significantly higher in screen-detected (93.8%) and lower in FIT non-participant CRCs (61.9%) vs. FIT interval cancers and CRCs in never-invited cases (67.6% and 66.7%, respectively). Organised FIT screening in Flanders clearly reduced CRC incidence (especially advanced-stage) and mortality (in men, but not yet in women). Survival is significantly better in screen-detected cases vs. CRCs in unscreened people. Our findings support the implementation of FIT organised screening and the continued effort to increase uptake.
Funder
Agency for Care and Health
Subject
Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health
Reference54 articles.
1. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries;Bray;CA Cancer J. Clin.,2018
2. Belgian Cancer Registry (2023, January 06). Cancer Fact Sheet Colorectal Cancer: Belgium 2020. Available online: https://kankerregister.org/media/docs/CancerFactSheets/2020/Cancer_Fact_Sheet_ColorectalCancer_2020.pdf.
3. The evolution of colorectal carcinoma;Morson;Clin. Radiol.,1984
4. Effectiveness of Colorectal Cancer Screening in Detecting Earlier-Stage Disease-A Nationwide Cohort Study in Denmark;Larsen;Gastroenterology,2018
5. Helsingen, L.M., and Kalager, M. (2022). Colorectal Cancer Screening—Approach, Evidence, and Future Directions. NEJM Evid., 1.
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献