Association of D-Dimer, C-Reactive Protein, and Ferritin with COVID-19 Severity in Pregnant Women: Important Findings of a Cross-Sectional Study in Northern Brazil
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Published:2023-07-20
Issue:14
Volume:20
Page:6415
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ISSN:1660-4601
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Container-title:International Journal of Environmental Research and Public Health
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language:en
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Short-container-title:IJERPH
Author:
Paixão Jenephy Thalita Rosa12, Santos Carolinne de Jesus Santos e12, França Ana Paula Figueiredo de Montalvão12, Lima Sandra Souza2, Laurentino Rogério Valois2ORCID, Fonseca Ricardo Roberto de Souza12ORCID, Vallinoto Antonio Carlos Rosário2ORCID, Oliveira-Filho Aldemir Branco3ORCID, Machado Luiz Fernando Almeida12ORCID
Affiliation:
1. Biology of Infectious and Parasitic Agents Post-Graduate Program, Federal University of Pará, Belém 66075-110, PA, Brazil 2. Virology Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil 3. Study and Research Group on Vulnerable Populations, Institute for Coastal Studies, Federal University of Pará, Bragança 68600-000, PA, Brazil
Abstract
Background: The COVID-19 pandemic has had a great impact on pregnant women due to the broad clinical spectrum of the disease. The present study investigated the profile of three biomarkers during hospital admission of pregnant women—D-dimer, C-reactive protein (CRP), and ferritin—and their correlation with the severity and outcome of COVID-19. Methods: The cross-sectional study included 226 pregnant women hospitalized in the city of Belém, Pará, Northern Brazil, from April 2020 to July 2021. Epidemiological and laboratory data were obtained from medical records, and all pregnant women underwent RT-PCR molecular testing for the detection of SARS-CoV-2. Results: In total, 121 (53.5%) were positive and 105 (46.5%) were negative for SARS-CoV-2 using RT-PCR. Most pregnant women (49.5%) with COVID-19 were between 26 and 34 years old, were residing in the interior of the state of Pará (51.2%), and were in the third gestational trimester (71.9%). In addition, 71.1% of them were admitted to the ward and 28.9% were admitted to the intensive care unit (ICU), with 90.9% surviving COVID-19. The concentrations of D-dimer (p = 0.0122) and ferritin (p ≤ 0.0001) were significantly higher among pregnant women with COVID-19, especially among those hospitalized in the ICU. Conclusion: Ferritin and D-dimer seem to serve as important biomarkers for the prognosis of COVID-19 in pregnant women, which was not observed for CRP.
Funder
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Ministry of Education—Brazil Public Notice PAPQ, PROPESP/FADESP of the Federal University of Pará
Subject
Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health
Reference39 articles.
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