Magnetic Resonance Imaging of Central Nervous System Manifestations of Type 1 Neurofibromatosis: Pictorial Review and Retrospective Study of Their Frequency in a Cohort of Patients

Author:

Di Pietro Stefano1ORCID,Reali Linda1,Tona Emanuela1ORCID,Belfiore Giuseppe1,Praticò Andrea Domenico2,Ruggieri Martino3,David Emanuele1,Foti Pietro Valerio1ORCID,Santonocito Orazio Giuseppe4,Basile Antonio1,Palmucci Stefano4ORCID

Affiliation:

1. Radiology Unit 1, Department of Medical Surgical Sciences and Advanced Technologies “GF Ingrassia”, University Hospital Policlinico “G. Rodolico-San Marco”, University of Catania, 95123 Catania, Italy

2. Faculty of Medicine and Surgery, University of Enna “Kore”, 94100 Enna, Italy

3. Unit of Clinical Pediatrics, Department of Clinical and Experimental Medicine, University of Catania, A.O.U. “Policlinico”, P.O. “G. Rodolico”, via S. Sofia, 78, 95125 Catania, Italy

4. UOSD “IPTRA”, Department of Medical Surgical Sciences and Advanced Technologies “GF Ingrassia”, University Hospital Policlinico “G. Rodolico-San Marco”, University of Catania, 95123 Catania, Italy

Abstract

Background: type 1 neurofibromatosis (NF1) is the most common neurocutaneous disorder, and it is an inherited condition that causes a tumour predisposition. Central nervous system (CNS) manifestations are a significant cause of morbidity and mortality in NF1. We provide a pictorial review of neuroradiological features of NF1, with emphasis on magnetic resonance imaging (MRI), and we assess the frequency of those features on a cohort of NF1 patients. Methods: we retrospectively evaluated all patients with a diagnosis of NF1 who underwent MRI of the spine and brain in our centre over a period of almost 5 years. A total of 74 patients were enrolled, 28 males and 46 females, with a mean age of 21 ± 12.67 years. The frequency of CNS manifestations encountered in our cohort of NF1 patients was assessed and compared with the data found in other studies published in the literature. Results: many of our findings were in line with the literature, and possible interpretations for those that turned out to be different were suggested in the discussion. Conclusion: imaging plays a central role in the diagnosis and management of NF1, and the knowledge of CNS manifestations could be critical for its early detection and identification, such as for treatment planning and prognostic implications.

Publisher

MDPI AG

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