Beyond the Coagulation Cascade: Vitamin K and Its Multifaceted Impact on Human and Domesticated Animal Health
-
Published:2024-07-04
Issue:7
Volume:46
Page:7001-7031
-
ISSN:1467-3045
-
Container-title:Current Issues in Molecular Biology
-
language:en
-
Short-container-title:CIMB
Author:
Sadler Rebecka A.1, Shoveller Anna K.1ORCID, Shandilya Umesh K.1ORCID, Charchoglyan Armen23, Wagter-Lesperance Lauraine24, Bridle Byram W.24ORCID, Mallard Bonnie A.24, Karrow Niel A.12
Affiliation:
1. Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada 2. ImmunoCeutica Inc., Cambridge, ON N1T 1N6, Canada 3. Advanced Analysis Centre, University of Guelph, Guelph, ON N1G 2W1, Canada 4. Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada
Abstract
Vitamin K (VK) is an essential micronutrient impacting many systems in the body. This lipid-soluble vitamin is found in various plant and animal products and is absorbed via the lymphatic system. This biomolecule’s importance to human health includes but is not limited to its promotion of brain, cardiovascular, bone, and immune functions. These biological properties are also necessary for maintaining domesticated animal health. The synergistic impact of both VK and vitamin D (VD) maximizes these health benefits, specifically for the circulatory and skeletal systems. This manuscript reviews VK’s properties, molecular structures, nutrikinetics, mechanisms of action, daily requirements, safety in supplemental form, biomarkers used for its detection, and impacts on various organs. The purpose of synthesizing this information is to evaluate the potential uses of VK for the treatment or prevention of diseases.
Funder
National Science and Engineering Research Council of Canada
Reference183 articles.
1. The Occurrence and Chemical Nature of Vitamin K;Dam;Biochem. J.,1936 2. Jadhav, N., Ajgaonkar, S., Saha, P., Gurav, P., Pandey, A., Basudkar, V., Gada, Y., Panda, S., Jadhav, S., and Mehta, D. (2022). Molecular Pathways and Roles for Vitamin K2-7 as a Health-Beneficial Nutraceutical: Challenges and Opportunities. Front. Pharmacol., 13. 3. Vitamin K and Rheumatoid Arthritis;Okamoto;IUBMB Life,2008 4. Vitamin K—Sources, Physiological Role, Kinetics, Deficiency, Detection, Therapeutic Use, and Toxicity;Carazo;Nutr. Rev.,2022 5. Halder, M., Petsophonsakul, P., Akbulut, A., Pavlic, A., Bohan, F., Anderson, E., Maresz, K., Kramann, R., and Schurgers, L. (2019). Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease. Int. J. Mol. Sci., 20.
|
|