Subgroup Analysis of TLR2, -3, -4 and -8 in Relation to the Severity of Clinical Manifestations of Cervical HPV Infection-Reference-Cited by-同舟云学术

Subgroup Analysis of TLR2, -3, -4 and -8 in Relation to the Severity of Clinical Manifestations of Cervical HPV Infection

Published:2024-09-08 Issue:17 Volume:25 Page:9719
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Dushkin Alexander¹^ORCID,Afanasiev Maxim²,Afanasiev Stanislav³,Grishacheva Tatiana⁴,Biryukova Elena²,Dushkina Irina⁵,Karaulov Alexander²

Affiliation:

1. Project Office, Moscow City Hospital 52, 123182 Moscow, Russia

2. Clinical Immunology and Allergology Department, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia

3. G.N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, Federal Service for the Oversight of Consumer Protection and Welfare, 125212 Moscow, Russia

4. Center of Laser Medicine, First Pavlov State Medical University of St. Petersburg, 192071 Saint-Petersburg, Russia

5. Gynecology Department, Moscow City Hospital 67, 123423 Moscow, Russia

Abstract

We present the findings of assessing the expression levels of extracellular TLR2 and TLR4 and intracellular TLR3 and TLR8 correlating with the severity of clinical manifestations of HPV infection. A total of 199 women took part in a single-center prospective comparative research study on TLR2, TLR3, TLR4 and TLR8 expression in HPV-related cervical lesions. TLRs’ mRNA expression was analyzed using real-time reverse transcription polymerase chain reaction (RT-PCR). Our results indicate the potential significance of TLR3, TLR4 and TLR8 in responding to HPV infection and its progression to SILs and CC, highlighting the importance of HPV polyinfection in relation to TLR4 and TLR8.

Publisher

MDPI AG

Link

https://www.mdpi.com/1422-0067/25/17/9719/pdf

Reference23 articles.

1. (2024, August 13). HPV Information Centre. Available online: https://hpvcentre.net/.

2. (2024, August 13). Cancer Today. Available online: https://gco.iarc.who.int/today/en.

3. Mirabello, L., Clarke, M.A., Nelson, C.W., Dean, M., Wentzensen, N., Yeager, M., Cullen, M., Boland, J.F., Alemany, L., and Banks, L. (2018). The Intersection of HPV Epidemiology, Genomics and Mechanistic Studies of HPV-Mediated Carcinogenesis. Viruses, 10.

4. HPV: From Infection to Cancer;Stanley;Biochem. Soc. Trans.,2007

5. The Role of Innate Immunity Receptors (TLRs) in Maintaining the Homeostasis of the Female Genital Tract in Developing Pregnancy and Intrauterine Infection;Borisova;Infektsiya Immun.,2018