SARS-CoV-2: Some Aspects of Molecular Evolution, Cellular Pathogenesis, and Immune System Mechanism Elusion

Author:

Quirino Angela,Marascio NadiaORCID,Barreca Giorgio Settimo,Gallo Luigia,Giancotti Aida,Lamberti Angelo GiuseppeORCID,Peronace Cinzia,Trecarichi Enrico MariaORCID,Fusco PaoloORCID,Mazzitelli MariaORCID,Divenuto Francesca,Pavia Grazia,Suraci Angela,Matera Giovanni,Liberto Maria Carla

Abstract

The purpose of this review is to address some of the latest aspects regarding molecular features, pathogenic mechanisms, and immune system response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on recent publications in this field from March 2020 to May 2021. Interpretation keys for periodic re-emergence of coronavirus infections and other lethal viral pandemics are suggested. Antibody-dependent enhancement (ADE) and other potential mechanisms of immune system deception are put forward. Therefore, vaccine development must take into account ADE and other unwanted side effects of immune-based medical intervention. Features reported in our review will allow both clinicians and basic science researchers to take home ideas to improve their knowledge about SARS-CoV-2.

Publisher

MDPI AG

Subject

Fluid Flow and Transfer Processes,Computer Science Applications,Process Chemistry and Technology,General Engineering,Instrumentation,General Materials Science

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