Engineering Fatty Acid Biosynthesis in Microalgae: Recent Progress and Perspectives-Reference-Cited by-同舟云学术

Engineering Fatty Acid Biosynthesis in Microalgae: Recent Progress and Perspectives

Published:2024-05-09 Issue:5 Volume:22 Page:216
ISSN:1660-3397
Container-title:Marine Drugs
language:en
Short-container-title:Marine Drugs

Author:

Song Yanhui¹²,Wang Fangzhong¹²³,Chen Lei¹²,Zhang Weiwen¹²³

Affiliation:

1. Laboratory of Synthetic Microbiology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China

2. Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin 300350, China

3. Center for Biosafety Research and Strategy, Tianjin University, Tianjin 300072, China

Abstract

Microalgal lipids hold significant potential for the production of biodiesel and dietary supplements. To enhance their cost-effectiveness and commercial competitiveness, it is imperative to improve microalgal lipid productivity. Metabolic engineering that targets the key enzymes of the fatty acid synthesis pathway, along with transcription factor engineering, are effective strategies for improving lipid productivity in microalgae. This review provides a summary of the advancements made in the past 5 years in engineering the fatty acid biosynthetic pathway in eukaryotic microalgae. Furthermore, this review offers insights into transcriptional regulatory mechanisms and transcription factor engineering aimed at enhancing lipid production in eukaryotic microalgae. Finally, the review discusses the challenges and future perspectives associated with utilizing microalgae for the efficient production of lipids.

Funder

the National Key R&D Program of China

Publisher

MDPI AG

Link

https://www.mdpi.com/1660-3397/22/5/216/pdf

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