Abstract
Serotonin syndrome (SS) is a clinical toxidrome with high variability in clinical practice. It develops due to increased serotonin levels in the central nervous system. With an underestimated frequency, SS can develop following an overdose, a therapeutic dose increase, or drug to drug interaction of at least one serotonergic agent. It can present with autonomic signs, neuromuscular changes and an altered mental status. However, history and clinical examination are key features to formulate the diagnosis. Treatment options consist of supportive measures, discontinuation of the offending agent and certain therapeutic agents previously reported to improve outcomes. Physicians have limited experience with SS, partially due to the lack of its identification in clinical practice. Therefore, we have integrated, in a narrative review, the case of a young male with SS following an atypical antipsychotic overdose superimposed on chronic treatment with agents previously known to produce SS.
Reference72 articles.
1. The serotonin syndrome;Boyer;N. Engl. J. Med.,2005
2. Serotonin syndrome: Preventing, recognizing, and treating it;Wang;Clevel. Clin. J. Med.,2016
3. Association Between Serotonin Syndrome and Second-Generation Antipsychotics via Pharmacological Target-Adverse Event Analysis;Racz;Clin. Transl. Sci.,2018
4. Antidepressants and the serotonin syndrome in general practice;Mackay;Br. J. Gen. Pract.,1999
5. Serotonin Syndrome in Children and Adolescents Exposed to Selective Serotonin Reuptake Inhibitors—A Review of Literature;Xuev;J. Can. Acad. Child Adolesc. Psychiatry,2021
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献