Abstract
Corynebacterium diphtheriae, the etiological agent of diphtheria, is a re-emerging pathogen, responsible for several thousand deaths per year. In addition to diphtheria, systemic infections, often by non-toxigenic strains, are increasingly observed. This indicates that besides the well-studied and highly potent diphtheria toxin, various other virulence factors may influence the progression of the infection. This review focuses on the known components of C. diphtheriae responsible for adhesion, invasion, inflammation, and cell death, as well as on the cellular signaling pathways activated upon infection.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference99 articles.
1. Untersuchungen über die Bedeutung der Mikroorganismen für die Entstehung der Diphtherie beim Menschen, bei der Taube und beim Kalbe;Löffler;Mitt. Dem Kais. Gesundh.,1884
2. Evolution, epidemiology and diversity of Corynebacterium diphtheriae : New perspectives on an old foe
3. Microbe Profile: Corynebacterium diphtheriae – an old foe always ready to seize opportunity
4. Diphtheria
5. Diphtheria and its etiological agents;Burkovski,2014
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