Abstract
Peripheral cytokines may affect the brain through chronic activation of microglia and, as a result, can potentially lead to decreased integrity of white matter of cingulum bundle (CB). Therefore, the aim of the study was to analyze the relationships between peripheral inflammatory markers and the integrity of the CB in various states: from healthy controls, through prodromal states and first-episode psychosis, to long-term schizophrenia. The integrity of the CB was measured using diffusion tensor imaging. We analyzed six parameters: CRP, IL-6, IL-8, IL-10, TNF-α, and IFN-γ. We found that levels of IL-6 and IFN-γ differed significantly between groups. Initial analysis showed some correlations between the inflammatory markers and CB integrity, in particular a correlation with IL-6 that was present in several groups. However, none of the analyzed parameters were associated with the integrity of the CB after correction for multiple comparisons. Conclusions: Our results supported our hypothesis that there are increased levels of inflammatory markers in psychotic disorders, but did not allow to confirm our hypothesis that there is a link between increased peripheral inflammatory markers and decreased integrity of the CB. However, we found some interesting trend levels that need to be verified in larger studies.
Funder
Ministry of Science and Higher Education
National Science Center
Pomeranian Medical University
Reference62 articles.
1. Simeone, J.C., Ward, A.J., Rotella, P., Collins, J., and Windisch, R. (2015). An Evaluation of Variation in Published Estimates of Schizophrenia Prevalence from 1990–2013: A Systematic Literature Review. BMC Psychiatry, 15.
2. Risk Syndromes in Psychiatry: A State-of-the-Art Overview;Raballo;Arch Psych. Psych.,2019
3. Monitoring and Care of Young People at Incipient Risk of Psychosis;Yung;Schizophr. Bull.,1996
4. The Natural History and Pathophysiology of Treatment Resistant Schizophrenia;Sheitman;J. Psychiatr. Res.,1998
5. Immune-Inflammatory Markers and Psychosis Risk: A Systematic Review and Meta-Analysis;Misiak;Psychoneuroendocrinology,2021
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献