Unveiling the Impact of Lactic Acid Bacteria on Blood Lipid Regulation for Cardiovascular Health-Reference-Cited by-同舟云学术

Unveiling the Impact of Lactic Acid Bacteria on Blood Lipid Regulation for Cardiovascular Health

Published:2024-07-09 Issue:7 Volume:10 Page:350
ISSN:2311-5637
Container-title:Fermentation
language:en
Short-container-title:Fermentation

Author:

Yilmaz Birsen¹^ORCID,Arslan Neslihan²,Şahin Teslime Özge²^ORCID,Ağadündüz Duygu²^ORCID,Ozogul Fatih³⁴^ORCID,Rocha João Miguel F.⁵⁶⁷^ORCID

Affiliation:

1. Department of Nutrition and Dietetics, Faculty of Health Sciences, Çukurova University, 01330 Adana, Türkiye

2. Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, 06490 Ankara, Türkiye

3. Department of Seafood Processing Technology, Faculty of Fisheries, Çukurova University, 01330 Adana, Türkiye

4. Biotechnology Research and Application Center, Cukurova University, 01330 Adana, Türkiye

5. Laboratório Associado, Escola Superior de Biotecnologia, CBQF—Centro de Biotecnologia e Química Fina, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal

6. LEPABE—Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias s/n, 4200-465 Porto, Portugal

7. ALiCE—Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias s/n, 4200-465 Porto, Portugal

Abstract

Lactic acid bacteria (LAB) are a group of microorganisms which are beneficial and well-characterized with respect to the flavor and texture of food products via fermentation. The accumulated literature has suggested that dietary intake of fermented foods rich in LAB is related to different health-promoting benefits; however, in recent years, emerging evidence suggests a contribution of LAB to blood lipid regulation and cardiovascular health via certain mechanisms. Different potential mechanisms for the lipid regulatory effects of LAB may include the interaction of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and bile salt hydrolase activity and bile salt metabolism; gut microbiome modulation; and regulation of mRNA expression of genes related to fat metabolism in animal models and human studies. This review comprehensively aims to answer whether/how LAB influence blood lipids in both animal models and human studies while also uncovering the underlying mechanisms linking LAB to lipid metabolism.

Publisher

MDPI AG

Link

https://www.mdpi.com/2311-5637/10/7/350/pdf

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