Scientific and Pharmaceutical Aspects of Christensenella minuta, a Promising Next-Generation Probiotic
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Published:2023-08-17
Issue:8
Volume:9
Page:767
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ISSN:2311-5637
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Container-title:Fermentation
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language:en
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Short-container-title:Fermentation
Author:
Pető Ágota12, Kósa Dóra12, Szilvássy Zoltán3, Fehér Pálma12, Ujhelyi Zoltán12ORCID, Kovács Gabriella4, Német István4, Pócsi István5, Bácskay Ildikó12ORCID
Affiliation:
1. Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, 4032 Debrecen, Hungary 2. Institute of Healthcare Industry, University of Debrecen, Nagyerdei Körút 98, 4032 Debrecen, Hungary 3. Department of Pharmacology and Pharmacotherapy, Faculty of General Medicine, University of Debrecen, Nagyerdei Körút 98, 4032 Debrecen, Hungary 4. Fluart Innovative Vaccines Ltd., Fő út 7, 2097 Pilisborosjenő, Hungary 5. Department of Molecular Biotechnology and Microbiology, Institute of Biotechnology, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, 4032 Debrecen, Hungary
Abstract
Christensenella minuta (C. minuta), a member of a recently described bacterial family, is one of the most heritable next-generation probiotics. Many observational studies confirmed that the relative abundance of C. minuta is associated with lean body types with a low host body mass index (BMI), and is also influenced by age, diet, and genetics. By utilizing its benefits, it could be suited to many therapies, including human and animal health as well. However, a reliable method for culturing the strain must also be developed to enable the therapeutic administration of the microbe. Sludge microfiltration could be a promising solution for large scale-up cultivation. In this review, different processing methods are also described from pharmaceutical aspects.
Funder
Thematic Excellence Program National Research, Development and Innovation Fund of Hungary European Union and the European Regional Development Fund
Subject
Plant Science,Biochemistry, Genetics and Molecular Biology (miscellaneous),Food Science
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