Affiliation:
1. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China
2. College of Animal Science and Technology, Hunan Biological and Electromechanical Polytechnic, Changsha 410128, China
Abstract
Lactobacillus delbrueckii garners interest for its contributions to gut microecological balance, diarrheal prevention and treatment, immune modulation, growth promotion, and meat quality enhancement in livestock. However, its impact on the gut microbiota and liver metabolism in weaned piglets is less documented. This study involved 80 Duroc-Landrace-Yorkshire weaned piglets aged 28 days, randomized into two groups with four replicates each and ten piglets per replicate. Over a 28-day period, the piglets were fed either a basal diet (control group) or the same diet supplemented with 0.1% Lactobacillus delbrueckii microcapsules (≥1.0 × 1010 CFU/g) (Lactobacillus delbrueckii group). The principal findings are as follows: During the initial phase of the experiment, supplementation with Lactobacillus delbrueckii increased the levels of L-phenylalanine and L-lysine in the liver while reducing the L-alanine levels, thereby enhancing the aminoacyl–tRNA synthesis pathway in weaned piglets. In the later phase, Lactobacillus delbrueckii supplementation boosted the liver arachidonic acid content, strengthening the arachidonic acid metabolic pathway in the piglets. The gut microbiota and their metabolites likely play a role in regulating these processes. These results indicate that, compared to the control group, Lactobacillus delbrueckii reduced weaning stress-induced liver damage and metabolic disorders, increased liver glycogen content, and enhanced liver antioxidant function by improving the metabolism of lipids and carbohydrates. Consequently, the liver functioned more healthily.
Funder
Hunan Province Natural Science Foundation key project
National Natural Science Foundation of China
Scientific Research Project of Education Department of Hunan Province
Reference40 articles.
1. Nomenclatural Considerations of Certain Species of Lactobacillus Beijerinck;Rogosa;Int. J. Syst. Evol. Microbiol.,1971
2. Biological Function of Lactobacillus delbrueckii and Its Application in Animal Production;Wen;Chin. J. Anim. Nutr.,2019
3. Lacticin, a bacteri-ocin produced by Lactobacillus delbrueckii subsp. Lactis;Toba;Lett. Appl. Microbiol.,1991
4. Progress of the Lactobacillus and Its Physiological Function;Dai;Agric. Prod. Process. (J. Agric. Sci.),2009
5. Hansen, P.A. (1968). Type Strains of Lactobacillus Species. A Report by the Taxonomic Subcommittee on Lactobacilli and Closely Related Organisms. R. A Subcommittee of the International Committee on Nomenclature of Bacteria of the International Association of Microbiological Societies, American Culture Collection. Corpus ID: 89670364.