Consumption of Extruded Sorghum SC319 Improved Gut Microbiota at Genus Level and Reduced Anthropometric Markers in Men with Overweight: A Randomized Controlled Clinical Trial

Author:

Lúcio Haira1ORCID,Anunciação Pamella1,da Silva Barbara1,da Silva Alessandra1ORCID,Queiroz Valéria2ORCID,de Carvalho Carlos3ORCID,Pinheiro-Sant’Ana Helena1,Martino Hercia1ORCID

Affiliation:

1. Nutrition and Health Department, Federal University of Viçosa, Campus Universitário, Av. Purdue, s/n, Viçosa 36570-900, MG, Brazil

2. Embrapa Milho e Sorgo, Rote MG 424, Km 65, Sete Lagoas 35701-970, MG, Brazil

3. Embrapa Agroindústria de Alimentos, Av. das Américas, nº 29.501, Guaratiba, Rio de Janeiro 23020-470, RJ, Brazil

Abstract

Background: Sorghum is a cereal source of energy, carbohydrates, resistant starch, proanthocyanidins, and 3-deoxyanthocyanins; it promotes satiety by slowing digestion and benefits intestinal health. Objective: This study investigated the effects of extruded sorghum SC319 consumption on intestinal health, weight loss, and inflammatory markers in men with overweight. Methods: This was a randomized, controlled, single-blind clinical trial. Twenty-one men were randomly allocated into one of two groups: the sorghum group (test), which received 40 g of extruded SC319 whole sorghum (n = 10), or the wheat group (control), which received 38 g of extruded whole wheat (n = 11) for eight weeks. Results: The sorghum consumption increased the weight loss intragroup, decreased the body fat percentage intergroup, and did not change inflammatory markers, while the wheat group had increased IL-6 levels compared to baseline. Short-chain fatty acid production, fecal pH, and α and β diversity indexes did not differ intra- and intergroup after interventions. However, sorghum consumption decreased genus levels of Clostridium_sensu_stricto 1, Dorea, and Odoribacter and increased CAG-873 and Turicibacter compared to baseline. Further, sorghum showed a tendency (p = 0.07) to decrease the proteobacteria phyla compared to wheat. Conclusion: Extruded sorghum SC319 improved intestinal microbiota and body composition and promoted weight loss, demonstrating its prebiotic potential.

Funder

Coordination for the Improvement of Higher Education Personnel

Foundation for Research Support of Minas Gerais

National Counsel of Technological and Scientific Development

Embrapa Agroindústria de Alimentos

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

Reference47 articles.

1. A review of current guidelines for the treatment of obesity;Cornier;Am. J. Manag. Care,2022

2. Kojta, I., Chacińska, M., and Błachnio-Zabielska, A. (2020). Obesity, Bioactive Lipids, and Adipose Tissue Inflammation in Insulin Resistance. Nutrients, 12.

3. Lipid and Glucose Metabolism in White Adipocytes: Pathways, Dysfunction and Therapeutics;Morigny;Nat. Rev. Endocrinol.,2021

4. Barata Cavalcanti, O., Barquera, S., Baur, L., Busch, V., Buse, K., Dietz, B., French, A., Jackson Leach, R., van Opzeeland, B., and Powis, J. (2022). Compiled by Tim Lobstein, Hannah Brinsden and Margot Neveux, with Input and Review from Acknowledgments, World Obesity Federation.

5. Diet, Gut Microbiota, and Obesity: Links with Host Genetics and Epigenetics and Potential Applications;Milagro;Adv. Nutr.,2019

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3