Abstract
Herein, a novel nitr[ogen-doped carbon dot (N-CD) fluorescence sensor with a dual emission ratio is developed using the microwave-assisted synthesis of m-phenylenediamine and spermidine. As a result of the fluorescence inner filtration effect (IFE) effect between morphine (MOR) and N-CD, the blue fluorescence of N-CDs at 350 nm was reduced in the presence of MOR, whereas the fluorescence of N-CDs at 456 nm increased substantially. The results demonstrated that the approach has a tremendous potential and that the linear range of MOR detection is 0.25–25 µg/mL, with a 71.8 ng/mL detection limit. Under UV light, the blue fluorescent system is easily visible to the naked eye. More significantly, the sensor proved successful in providing satisfactory results for the speciation measurement of MOR in a variety of biological samples.
Funder
National Natural Science Foundation of China
National Innovation and Entrepreneurship Training Program for College Student of China
Opening Project of Key Laboratory of Ministry of Public Security for Drug Analysis and Anti-Drug Technology
Basic Research Project of Yunnan Province/General Project
Subject
Clinical Biochemistry,General Medicine,Analytical Chemistry,Biotechnology,Instrumentation,Biomedical Engineering,Engineering (miscellaneous)
Cited by
2 articles.
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