Palladium Hydroxide (Pearlman’s Catalyst) Doped MXene (Ti3C2Tx) Composite Modified Electrode for Selective Detection of Nicotine in Human Sweat

Author:

Magesh VasanthORCID,Sundramoorthy Ashok K.ORCID,Ganapathy Dhanraj,Atchudan RajiORCID,Arya SandeepORCID,Alshgari Razan A.ORCID,Aljuwayid Ahmed Muteb

Abstract

High concentrations of nicotine (40 to 60 mg) are more dangerous for adults who weigh about 70 kg. Herein, we developed an electrochemical transducer using an MXene (Ti3C2Tx)/palladium hydroxide-supported carbon (Pearlman’s catalyst) composite (MXene/Pd(OH)2/C) for the identification of nicotine levels in human sweat. Firstly, the MXene was doped with Pd(OH)2/C (PHC) by mechanical grinding followed by an ultrasonication process to obtain the MXene/PHC composite. Secondly, XRD, Raman, FE-SEM, EDS and E-mapping analysis were utilized to confirm the successful formation of MXene/PHC composite. Using MXene/PHC composite dispersion, an MXene/PHC composite-modified glassy carbon electrode (MXene/PHC/GCE) was prepared, which showed high sensitivity as well as selectivity towards nicotine (300 µM NIC) oxidation in 0.1 M phosphate buffer (pH = 7.4) by cyclic voltammetry (CV) and amperometry. The MXene/PHC/GCE had reduced the over potential of nicotine oxidation (about 200 mV) and also enhanced the oxidation peak current (8.9 µA) compared to bare/GCE (2.1 µA) and MXene/GCE (5.5 µA). Moreover, the optimized experimental condition was used for the quantification of NIC from 0.25 µM to 37.5 µM. The limit of detection (LOD) and sensitivity were 27 nM and 0.286 µA µM−1 cm2, respectively. The MXene/PHC/GCE was also tested in the presence of Na+, Mg2+, Ca2+, hydrogen peroxide, acetic acid, ascorbic acid, dopamine and glucose. These molecules were not interfered during NIC analysis, which indicated the good selectivity of the MXene/PHC/GCE sensor. In addition, electrochemical determination of NIC was successfully carried out in the human sweat samples collected from a tobacco smoker. The recovery percentage of NIC in the sweat sample was 97%. Finally, we concluded that the MXene/PHC composite-based sensor can be prepared for the accurate determination of NIC with high sensitivity, selectivity and stability in human sweat samples.

Funder

Science and Engineering Research Board (SERB), India and Department of Science and Technology, India

King Saud University, Riyadh, Saudi Arabia

Publisher

MDPI AG

Subject

Clinical Biochemistry,General Medicine,Analytical Chemistry,Biotechnology,Instrumentation,Biomedical Engineering,Engineering (miscellaneous)

Reference74 articles.

1. In Vitro Anthelmintic Effect of Tobacco (Nicotiana Tabacum) Extract on Parasitic Nematode, Marshallagia Marshalli;Nouri;J. Parasit. Dis. Off. Organ Indian Soc. Parasitol.,2016

2. Cardiovascular Toxicity of Nicotine: Implications for Electronic Cigarette Use;Benowitz;Trends Cardiovasc. Med.,2016

3. US Department of Health and Human Services (2010). The Biology and Behavioral Basis for Smoking-Attributable Disease: A Report of the Surgeon General, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health.

4. The Relationship among Internal Resilience, Smoking, Alcohol Use, and Depression Symptoms in Emerging Adults Transitioning out of Child Welfare;Goldstein;Child Abuse Negl.,2013

5. In-Silico Study of Toxicokinetics and Disease Association of Chemicals Present in Smokeless Tobacco Products;Bhartiya;Regul. Toxicol. Pharmacol.,2018

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3