Particulate Matter Induced Adverse Effects on Eye Development in Zebrafish (Danio rerio) Embryos-Reference-Cited by-同舟云学术

Particulate Matter Induced Adverse Effects on Eye Development in Zebrafish (Danio rerio) Embryos

Published:2024-01-11 Issue:1 Volume:12 Page:59
ISSN:2305-6304
Container-title:Toxics
language:en
Short-container-title:Toxics

Author:

Priyadarshana Dalawalla G. Charith E.¹,Cheon Jayeon²,Lee Yoonsung³^ORCID,Cha Seon-Heui¹²^ORCID

Affiliation:

1. Department of Integrated Bioindustry, Hanseo University, Seosan-si 31962, Republic of Korea

2. Department of Marine Bio and Medical Sciences, Hanseo University, Seosan-si 31962, Republic of Korea

3. Clinical Research Institute, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul 05278, Republic of Korea

Abstract

Particulate matter (PM) can cause human diseases, particularly respiratory diseases. Since eyes are directly exposed to the air, they might be directly adversely affected by PM. Therefore, we determined the toxicity caused to eye development by PM using zebrafish (Danio rerio) embryos. The PM-induced embryo toxicity was dependent on dose and time and caused significant morphological defects, reducing the total body length and the total eye area. Reactive oxygen species (ROS) overproduction was confirmed in the PM treatment group, and antioxidant genes (cat and sod2), photoreceptor cell development, pigmentation genes (atoh8, vsx1, and rho), eye-embryogenesis genes (pax6a and pax6b), and eye-lens-development genes (cryaa) were downregulated, while eye-development genes (crybb1) were upregulated. In conclusion, PM had a direct adverse effect on the eyes, and zebrafish embryos can be used as a model to evaluate PM-induced eye toxicity in vivo.

Funder

Ministry of Science, ICT, and Future Planning

Publisher

MDPI AG

Subject

Chemical Health and Safety,Health, Toxicology and Mutagenesis,Toxicology

Link

https://www.mdpi.com/2305-6304/12/1/59/pdf

Reference48 articles.

1. WHO (2013). Review of Evidence on Health Aspects of Air Pollution, World Health Organization.

2. Particulate Matter Air Pollution: Effects on the Cardiovascular System;Hamanaka;Front. Endocrinol.,2018

3. WHO (2023, November 01). Ambient (Outdoor) Air Quality and Health. Available online: https://www.who.int/zh/news-room/fact-sheets/detail/ambient-(outdoor)-air-quality-and-health.

4. Correlation between Signs and Symptoms of Ocular Surface Dysfunction and Tear Osmolarity with Ambient Levels of Air Pollution in a Large Metropolitan Area;Torricelli;Cornea,2013

5. WHO (2006). Air Quality Guidelines for Particulate Matter, Ozone, Nitrogen Dioxide and Sulphur Dioxide. Global Update 2005, World Health Organization. Available online: https://www.who.int/publications/i/item/WHO-SDE-PHE-OEH-06.02.