Abstract
The present review covers combination approaches of antimicrobial photodynamic therapy (aPDT) plus antibiotics or antifungals to attack bacteria and fungi in vitro (both planktonic and biofilm forms) focused on those microorganisms that cause infections in skin and soft tissues. The combination can prevent failure in the fight against these microorganisms: antimicrobial drugs can increase the susceptibility of microorganisms to aPDT and prevent the possibility of regrowth of those that were not inactivated during the irradiation; meanwhile, aPDT is effective regardless of the resistance pattern of the strain and their use does not contribute to the selection of antimicrobial resistance. Additive or synergistic antimicrobial effects in vitro are evaluated and the best combinations are presented. The use of combined treatment of aPDT with antimicrobials could help overcome the difficulty of fighting high level of resistance microorganisms and, as it is a multi-target approach, it could make the selection of resistant microorganisms more difficult.
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Cited by
17 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Current challenges in acute bacterial skin infection management;Current Opinion in Infectious Diseases;2024-01-04
2. Important Advances in Antibacterial Nanoparticle-Mediated Photodynamic Therapy;Recent Advances in Bacterial Biofilm Studies - Formation, Regulation, and Eradication in Human Infections [Working Title];2023-12-21
3. Cationic Porphyrins as Antimicrobial and Antiviral Agents in Photodynamic Therapy;Current Issues in Molecular Biology;2023-12-06
4. Antibacterial and Antifungal Materials;Carrier-mediated Gene and Drug Delivery for Dermal Wound Healing;2023-08-11
5. Photosensitizers combination approach to enhance photodynamic inactivation of planktonic and biofilm bacteria;Photochemical & Photobiological Sciences;2023-07-25