Splenic Rupture Secondary to Amyloidosis: A Case Report and Review of the Literature-Reference-Cited by-同舟云学术

Splenic Rupture Secondary to Amyloidosis: A Case Report and Review of the Literature

Published:2023-06-06 Issue:2 Volume:15 Page:370-383
ISSN:2038-8330
Container-title:Hematology Reports
language:en
Short-container-title:Hematology Reports

Author:

Bahmad Hisham F.¹^ORCID,Gogola Samantha²^ORCID,Burton Lorena³,Alloush Ferial¹,Cusnir Mike⁴,Schwartz Michael⁴,Howard Lydia¹⁵,Sriganeshan Vathany¹⁵

Affiliation:

1. The Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA

2. Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA

3. Department of Internal Medicine, Mount Sinai Medical Center, FL 33140, USA

4. Department of Internal Medicine, Division of Hematology and Oncology, Mount Sinai Medical Center, Miami Beach, FL 33140, USA

5. Department of Pathology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA

Abstract

Amyloidosis is a term describing the extracellular deposit of fibrils composed of subunits of several different normal serum proteins in various tissues. Amyloid light chain (AL) amyloidosis contains fibrils that are composed of fragments of monoclonal light chains. Many different disorders and conditions can lead to spontaneous splenic rupture, including AL amyloidosis. We present a case of a 64-year-old woman with spontaneous splenic rupture and hemorrhage. A final diagnosis of systemic amyloidosis secondary to plasma cell myeloma was made with infiltrative cardiomyopathy and possible diastolic congestive heart failure exacerbation. We also provide a narrative review of all documented cases of splenic rupture associated with amyloidosis from the year 2000 until January 2023, along with the main clinical findings and management strategies.

Publisher

MDPI AG

Subject

Hematology

Link

https://www.mdpi.com/2038-8330/15/2/38/pdf

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