Attention-Based Active Learning Framework for Segmentation of Breast Cancer in Mammograms

Abstract

Breast cancer is one of most serious malignant tumors that affect women’s health. To carry out the early screening of breast cancer, mammography provides breast cancer images for doctors’ efficient diagnosis. However, breast cancer lumps can vary in size and shape, bringing difficulties for the accurate recognition of both humans and machines. Moreover, the annotation of such images requires expert medical knowledge, which increases the cost of collecting datasets to boost the performance of deep learning methods. To alleviate these problems, we propose an attention-based active learning framework for breast cancer segmentation in mammograms; the framework consists of a basic breast cancer segmentation model, an attention-based sampling scheme and an active learning strategy for labelling. The basic segmentation model performs multi-scale feature fusion and enhancement on the basis of UNet, thus improving the distinguishing representation capability of the extracted features for further segmentation. Afterwards, the proposed attention-based sampling scheme assigns different weights for unlabeled breast cancer images by evaluating their uncertainty with the basic segmentation model. Finally, the active learning strategy selects unlabeled images with the highest weights for manual labeling, thus boosting the performance of the basic segmentation model via retraining with new labeled samples. Testing on four datasets, experimental results show that the proposed framework could greatly improve segmentation accuracy by about 15% compared with an existing method, while largely decreasing the cost of data annotation.