Omega-3 Polyunsaturated Fatty Acid Levels in Maternal and Cord Plasma Are Associated with Maternal Socioeconomic Status
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Published:2023-10-19
Issue:20
Volume:15
Page:4432
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ISSN:2072-6643
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Container-title:Nutrients
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language:en
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Short-container-title:Nutrients
Author:
Hergenrader Alexandra1, VanOrmer Matthew1ORCID, Slotkowski Rebecca1ORCID, Thompson Maranda1ORCID, Freeman Alyssa1, Paetz Olivia1, Sweeney Sarah1, Wegner Lauren1, Ali Khadijjta1, Bender Nicole1ORCID, Chaudhary Ridhi1, Thoene Melissa1, Hanson Corrine2, Anderson-Berry Ann1ORCID
Affiliation:
1. Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE 68198, USA 2. Medical Nutrition Education Program, College of Allied Health, University of Nebraska Medical Center, Omaha, NE 68198, USA
Abstract
Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) play a crucial role in fetal growth and neurodevelopment, while omega-6 (n-6) PUFAs have been associated with adverse pregnancy outcomes. Previous studies have demonstrated that socioeconomic status (SES) influences dietary intake of n-3 and n-6 PUFAs, but few studies have evaluated the association between maternal and cord plasma biomarkers of PUFAs and socioeconomic markers. An IRB-approved study enrolled mother–infant pairs (n = 55) at the time of delivery. Maternal and cord plasma PUFA concentrations were analyzed using gas chromatography. Markers of SES were obtained from validated surveys and maternal medical records. Mann–Whitney U tests and linear regression models were utilized for statistical analysis. Maternal eicosapentaenoic acid (EPA) (p = 0.02), cord EPA (p = 0.04), and total cord n-3 PUFA concentrations (p = 0.04) were significantly higher in college-educated mothers vs. mothers with less than a college education after adjustment for relevant confounders. Insurance type and household income were not significantly associated with n-3 or n-6 PUFA plasma concentrations after adjustment. Our findings suggest that mothers with lower educational status may be at risk of lower plasma concentrations of n-3 PUFAs at delivery, which could confer increased susceptibility to adverse pregnancy and birth outcomes.
Funder
University of Nebraska Medical Center Department of Pediatrics and Child Health Research Institute
Subject
Food Science,Nutrition and Dietetics
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