Relative Telomere Length Is Associated with the Risk of Development and Severity of the Course of Age-Related Macular Degeneration in the Russian Population
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Published:2023-07-12
Issue:14
Volume:24
Page:11360
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ISSN:1422-0067
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Container-title:International Journal of Molecular Sciences
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language:en
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Short-container-title:IJMS
Author:
Dmitrenko Olga P.1ORCID, Abramova Olga I.2, Karpova Nataliia S.1ORCID, Nurbekov Malik K.1, Arshinova Ekaterina S.1
Affiliation:
1. Laboratory of Regulation of Reparative Processes, Federal State Budgetary Institution “Research Institute of Pathology and Pathophysiology”, 125315 Moscow, Russia 2. Department of Ophthalmology, Federal State Budgetary Educational Institution of Continuing Professional Education “Russian Medical Academy of Continuing Professional Education” of the Ministry of Health of the Russian Federation, 125993 Moscow, Russia
Abstract
One of the most significant factors for age-related macular degeneration (AMD) development is considered to be aging, the processes of which are closely associated with telomere shortening. The different forms, indicators of aggressiveness, and intensities of AMD can be observed in the same age group, confirming the need to find a biomarker for early diagnosis and be capable of monitoring the progression of the pathological process. Therefore, we investigated whether the relative telomere length (RTL) has any connection with the risk of development of disease and its progression. RTL was measured using RT-PCR in 166 people, including 96 patients with AMD. RTL was significantly lower in patients with AMD. Women were more likely to develop AMD than men (odds ratio (OR) = 9.53 × 106 vs. OR = 1.04 × 108, respectively). The decrease in RTL in patients reliably correlated with the progression of AMD, and the smallest RTL was observed in late-stage patients. RTL < 0.8 is a significant risk factor for disease progression. The results of our research showed that RTL may be considered as a potential biomarker and a promising predictor of disease progression in patients with early AMD.
Funder
Federal State Budgetary Institution, the “Research Institute of Pathology and Pathophysiology”
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference37 articles.
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