Paclitaxel Delivery to the Brain for Glioblastoma Treatment-Reference-Cited by-同舟云学术

Paclitaxel Delivery to the Brain for Glioblastoma Treatment

Published:2023-07-21 Issue:14 Volume:24 Page:11722
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

AbdEl-haq Muhammad¹,Kumar Awanish¹,Ait Mohand Fatima-ezzahra²,Kravchenko-Balasha Nataly²^ORCID,Rottenberg Yakir³,Domb Abraham J.¹^ORCID

Affiliation:

1. Institute of Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel

2. The Institute of Biomedical and Oral Research, Faculty of Dental Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel

3. Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel

Abstract

The development of paclitaxel-loaded polymeric nanoparticles for the treatment of brain tumors was investigated. Poly(lactide-glycolide) (PLGA) nanoparticles containing 10% w/w paclitaxel with a particle size of 216 nm were administered through intranasal and intravenous routes to male Sprague–Dawley rats at a dose of 5 mg/kg. Both routes of administration showed appreciable accumulation of paclitaxel in brain tissue, liver, and kidney without any sign of toxicity. The anti-proliferative effect of the nanoparticles on glioblastoma tumor cells was comparable to that of free paclitaxel.

Funder

Israel Cancer Research Fund

Israel Cancer Association Grant

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/14/11722/pdf

Reference53 articles.

1. Formulations for Intranasal Delivery of Pharmacological Agents to Combat Brain Disease: A New Opportunity to Tackle GBM?;Wauthoz;Cancers,2013

2. Mechanism of intranasal drug delivery directly to the brain;Crowe;Life Sci.,2018

3. Intranasal drug delivery: Opportunities and toxicologic challenges during drug development;Keller;Drug Deliv. Transl. Res.,2022

4. Ghadiri, M., Young, P.M., and Traini, D. (2019). Strategies to Enhance Drug Absorption via Nasal and Pulmonary Routes. Pharmaceutics, 11.

5. Nasal mucoadhesive drug delivery: Background, applications, trends and future perspectives;Ugwoke;Adv. Drug Deliv. Rev.,2005

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Focused ultrasound blood-brain barrier disruption in high-grade gliomas: Scoping review of clinical studies;Journal of Clinical Neuroscience;2024-10

2. Phytocompounds and Nanoformulations for Anticancer Therapy: A Review;Molecules;2024-08-09

3. Progress in the Treatment of Central Nervous System Diseases Based on Nanosized Traditional Chinese Medicine;Advanced Science;2024-02-28

4. Early investigation of a novel SI306 theranostic prodrug for glioblastoma treatment;Drug Development Research;2024-02