The Advances in Glioblastoma On-a-Chip for Therapy Approaches

Author:

Alves Arielly H.,Nucci Mariana P.ORCID,Mamani Javier B.,Valle Nicole M. E.ORCID,Ribeiro Eduarda F.,Rego Gabriel N. A.,Oliveira Fernando A.ORCID,Theinel Matheus H.,Santos Ricardo S.,Gamarra Lionel F.

Abstract

This systematic review aimed to verify the use of microfluidic devices in the process of implementing and evaluating the effectiveness of therapeutic approaches in glioblastoma on-a-chip, providing a broad view of advances to date in the use of this technology and their perspectives. We searched studies with the variations of the keywords “Glioblastoma”, “microfluidic devices”, “organ-on-a-chip” and “therapy” of the last ten years in PubMed and Scopus databases. Of 446 articles identified, only 22 articles were selected for analysis according to the inclusion and exclusion criteria. The microfluidic devices were mainly produced by soft lithography technology, using the PDMS material (72%). In the microenvironment, the main extracellular matrix used was collagen type I. Most studies used U87-MG glioblastoma cells from humans and 31.8% were co-cultivated with HUVEC, hCMEC/D3, and astrocytes. Chemotherapy was the majority of therapeutic approaches, assessing mainly the cellular viability and proliferation. Furthermore, some alternative therapies were reported in a few studies (22.6%). This study identified a diversity of glioblastoma on-a-chip to assess therapeutic approaches, often using intermediate levels of complexity. The most advanced level implemented the intersection between different biological systems (liver–brain or intestine–liver–brain), BBB model, allowing in vitro studies with greater human genetic similarity, reproducibility, and low cost, in a highly customizable platform.

Funder

National Council for Scientific and Technological Development

São Paulo Research Foundation

Fundação de Amparo à Pesquisa do Espírito Santo

SisNANO 2.0/MCTIC

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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