Affiliation:
1. Department of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
Abstract
MRONJ is a serious drug-related side effect that is most common in people using antiresorptive and/or angiogenic medications. Therapy options for this condition include conservative treatments, surgical procedures with varied degrees of invasiveness, and adjuvant therapies. The aim of the present study is to identify the most successful and promising therapy alternatives available to clinicians. PubMed, Cochrane, Scopus, Web of Science, and Embase were searched for works on our topic published between 8 January 2006 and 8 January 2023. The search was restricted to randomized clinical trials, retrospective studies, clinical studies, and case series involving human subjects with at least five cases and no age restriction on participants. A total of 2657 was found. After the selection process, the review included 32 publications for qualitative analysis. Although conservative treatments (pharmacological, laser, and minimally invasive surgery) are effective in the early stages of MRONJs or as a supplement to traditional surgical resection therapy, most studies emphasize the importance of surgical treatment for the resolution or downstaging of advanced lesions. Fluorescence-guided surgery, PRP, PRF, CGF, piezosurgery, VEGF, hyaluronic acid, and ozone therapy all show significant potential for improving treatment outcomes.
Subject
Fluid Flow and Transfer Processes,Computer Science Applications,Process Chemistry and Technology,General Engineering,Instrumentation,General Materials Science
Reference128 articles.
1. The Frequency of Medication-Related Osteonecrosis of the Jaw and Its Associated Risk Factors;Dodson;Oral Maxillofac. Surg. Clin. N. Am.,2015
2. Stage-Specific Therapeutic Strategies of Medication-Related Osteonecrosis of the Jaws: A Systematic Review and Meta-Analysis of the Drug Suspension Protocol;Ramaglia;Clin. Oral Investig.,2018
3. Reply: AAOMS Position Paper on Medication-Related Osteonecrosis of the Jaws-2022 Update. Diagnostic Milestones, Doubts, and Perspectives on MRONJ;Ruggiero;J. Oral Maxillofac. Surg.,2022
4. Global, Regional, and National Incidence, Prevalence, and Years Lived with Disability for 328 Diseases and Injuries for 195 Countries, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016;Vos;Lancet,2017
5. Medication-Related Osteonecrosis of the Jaw: Clinical and Practical Guidelines;Rosella;J. Int. Soc. Prev. Community Dent.,2016
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献