Neurite Damage in Patients with Migraine

Author:

Shibata Yasushi1ORCID,Ishiyama Sumire2ORCID

Affiliation:

1. Department of Neurosurgery, Headache Clinic, Mito Medical Center, University of Tsukuba, Mito Kyodo General Hospital, Mito 3100015, Japan

2. Center for Medical Sciences, Ibaraki Prefectural University of Health Sciences, Ami 3000394, Japan

Abstract

We examined neurite orientation dispersion and density imaging in patients with migraine. We found that patients with medication overuse headache exhibited lower orientation dispersion than those without. Moreover, orientation dispersion in the body of the corpus callosum was statistically negatively correlated with migraine attack frequencies. These findings indicate that neurite dispersion is damaged in patients with chronic migraine. Our study results indicate the orientation preference of neurite damage in migraine.

Funder

JSPS KAKENHI

Publisher

MDPI AG

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