Contingent Negative Variation in the Evaluation of Neurocognitive Disorders Due to Possible Alzheimer’s Disease-Reference-Cited by-同舟云学术

Contingent Negative Variation in the Evaluation of Neurocognitive Disorders Due to Possible Alzheimer’s Disease

Published:2024-01-11 Issue:1 Volume:16 Page:126-138
ISSN:2035-8377
Container-title:Neurology International
language:en
Short-container-title:Neurology International

Author:

Montoya-Pedrón Arquímedes¹,Ocaña Montoya Carmen María²,Santos Toural Jorge Esteban³^ORCID,Acosta Lee Tania¹,Sánchez-Hechavarría Miguel Enrique⁴⁵⁶^ORCID,López-Galán Erislandis⁷^ORCID,Muñoz-Bustos Gustavo Alejandro⁸^ORCID

Affiliation:

1. Department of Clinical Neurophysiology, General Hospital “Dr. Juan Bruno Zayas Alfonso”, Santiago de Cuba 90100, Cuba

2. Hospital Infantil Sur, Santiago de Cuba 90100, Cuba

3. Telecommunications Department, Universidad de Oriente, Santiago de Cuba 90500, Cuba

4. Departamento de Ciencias Clínicas y Preclínicas, Facultad de Medicina, Universidad Católica de la Santísima Concepción, Concepción 4070129, Chile

5. Núcleo Científico de Ciencias de la Salud, Facultad de Ciencias de la Salud, Universidad Adventista de Chile, Chillán 8320000, Chile

6. Laboratorio de Psicología, Departamento de Psicología, Universidad de Concepción, Concepción 4070386, Chile

7. Facultad de Medicina 2, Universidad de Ciencias Médicas de Santiago de Cuba, Santiago de Cuba 90100, Cuba

8. Escuela de Kinesiología, Facultad de Salud y Ciencias Sociales, Campus El Boldal, Sede Concepción, Universidad de Las Américas, Concepción 4030000, Chile

Abstract

The usefulness of Contingent Negative Variation (CNV) potential as a biomarker of neurocognitive disorders due to possible Alzheimer’s disease, is based on its possible physiological correlates. However, its application in the diagnostic evaluation of these disorders is still incipient. The aim of this study is to characterize the patterns of cognitive processing of information in the domain of nonspecific global attention, by recording potential CNV in a group of patients with neurocognitive disorders due to possible Alzheimer’s disease. An experimental study of cases and controls was carried out. The sample included 39 patients classified according to DSM-5 with a neurocognitive disorder subtype possibly due Alzheimer’s disease, and a Control Group of 53 subjects with normal cognitive functions. CNV potential was registered using standard protocol. The analysis of variance obtained significant differences in mean values and confidence intervals of total CNV amplitude between the three study groups. The late CNV segment amplitudes makes it possible to discriminate between the level of mild and major dysfunction in the group of patients. The CNV total amplitudes of potential allows for effective discrimination between normal cognitive functioning and neurocognitive disorders due to possible Alzheimer’s disease.

Funder

Apoyo a la Publicaciones Open Access de la Universidad de Las Americas de Chile

Publisher

MDPI AG

Subject

Neurology (clinical)

Link

https://www.mdpi.com/2035-8377/16/1/8/pdf

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