Affiliation:
1. Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China
2. Department of Cardiology, Children’s Hospital Affiliated to Capital Institute of Pediatrics, Beijing 100020, China
Abstract
The mechanism of hypertension in children remains elusive. The objective of this study was to analyze plasma metabolomics characteristics to explore the potential mechanism of hypertension in children. Serum samples from 29 control children, 38 children with normal body mass index and simple hypertension (NBp), 8 children overweight with simple hypertension (OBp), 37 children with normal body mass index and H-type hypertension (NH) and 19 children overweight with H-type hypertension (OH) were analyzed by non-targeted metabolomics. A total of 1235 differential metabolites were identified between children with hypertension and normal controls, of which 193 metabolites including various lipids were significantly expressed. Compared with the control group, 3-dehydroepiandrosterone sulfate, oleic acid and linoleic acid were up-regulated, and gamma-muricholic acid was down-regulated in the NBp group; 3-dehydroepiandrosterone sulfate, 4-acetamidobutanoate and 1-hexadecanoyl-2-octadecadienoyl-sn-glyero-3-phosphocholine were up-regulated in the OBp group, whereas adenosine and 1-myristoyl-sn-glyero-3-phosphocholine were down-regulated; in the NH group, 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine, phenol and 3-methoxytyramine were up-regulated, while pentadecanoic acid was down-regulated; in the OH group, NG,NG-dimethyl-L-arginine, 1-palmitoyl-sn-glycero-3-phosphocholine and monoethyl phthalate were up-regulated, while phloretin and glycine were down-regulated. The results showed that the children with hypertension had obvious disorders of lipid metabolism (especially in the overweight hypertension group), which led to the occurrence of hypertension. Additionally, the concentration of NO production-related NG, NG-dimethyl-L-arginine, was significantly increased, which may play an important role in H-type hypertension in children.
Funder
National Natural Science Foundation
Public Service Development and Reform Pilot Project of Beijing Medical Research Institute
Research Foundation of the Capital Institute of Pediatrics
Beijing Municipal Science and Technology Commission
Capital’s Funds for Health Improvement and Research
National Natural Science Foundation of China
Subject
Food Science,Nutrition and Dietetics
Reference70 articles.
1. Joint Committee for Guideline Revision (2019). 2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Committee of Chinese Guidelines for Prevention and Treatment of Hypertension. J. Geriatr. Cardiol., 16, 182–241.
2. 2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents;Lurbe;J. Hypertens.,2016
3. The enigma of primary hypertension in childhood;Falkner;Front. Cardiovasc. Med.,2022
4. Global Prevalence of Hypertension in Children: A Systematic Review and Meta-analysis;Song;JAMA Pediatr.,2019
5. Prevalence of hypertension and hypertension phenotypes after three visits in Chinese urban children;Dong;J. Hypertens.,2022
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