Oat (Avena sativa L.) Sprouts Restore Skin Barrier Function by Modulating the Expression of the Epidermal Differentiation Complex in Models of Skin Irritation

Author:

Kim Hyo-Sung1,Hwang Hyun-Jeong1,Seo Woo-Duck2ORCID,Do Sun-Hee1ORCID

Affiliation:

1. Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul 05029, Republic of Korea

2. Division of Crop Foundation, National Institute of Crop Science, Rural Development Administration, Wanju 55365, Republic of Korea

Abstract

Oats (Avena sativa L.) are used as therapeutic plants, particularly in dermatology. Despite numerous studies on their skin moisturization, anti-inflammation, and antioxidation effects, the precise molecular mechanisms of these effects are only partially understood. In this study, the efficacy of oat sprouts in the treatment of allergic contact dermatitis (ACD) was investigated, and their specific phytoconstituents and exact mechanisms of action were identified. In the in vivo ACD model, by stimulating the mitogen-activated protein kinase signaling pathway, oat sprouts increased the expression levels of proteins associated with skin barrier formation, which are produced during the differentiation of keratinocytes. In addition, in a lipopolysaccharide-induced skin irritation model using HaCaT, steroidal saponins (avenacoside B and 26-deglucoavenacoside B) and a flavonoid (isovitexin-2-o-arabinoside) of oat sprouts regulated the genetic expression of the same proteins located on the adjacent locus of human chromosomes known as the epidermal differentiation complex (EDC). Furthermore, oat sprouts showed immunomodulatory functions. These findings suggest the potential for expanding the use of oat sprouts as a treatment option for various diseases characterized by skin barrier disruption.

Funder

Rural Development Administration

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Reference29 articles.

1. Avena sativa (Oat), a potential neutraceutical and therapeutic agent: An overview;Singh;Crit. Rev. Food Sci. Nutr.,2013

2. In vitro antioxidant capacity and anti-inflammatory activity of seven common oats;Chu;Food Chem.,2013

3. Cholesterol-lowering effects of oat beta-glucan: A meta-analysis of randomized controlled trials;Whitehead;Am. J. Clin. Nutr.,2014

4. Avena Rhealba inhibits A23187-stimulated arachidonic acid mobilization, eicosanoid release, and cPLA2 expression in human keratinocytes: Potential in cutaneous inflammatory disorders;Aries;Biol. Pharm. Bull.,2005

5. Anti-inflammatory activities of colloidal oatmeal (Avena sativa) contribute to the effectiveness of oats in treatment of itch associated with dry, irritated skin;Reynertson;J. Drugs Dermatol.,2015

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