Preparation of Tryptanthrin Derivates Bearing a Thiosemicarbazone Moiety to Inhibit SARS-CoV-2 Replication-Reference-Cited by-同舟云学术

Preparation of Tryptanthrin Derivates Bearing a Thiosemicarbazone Moiety to Inhibit SARS-CoV-2 Replication

Published:2023-01-20 Issue:2 Volume:10 Page:73
ISSN:2297-8739
Container-title:Separations
language:en
Short-container-title:Separations

Author:

Veselá Kateřina¹²³^ORCID,Mělková Zora²³⁴,Abramenko Nikita²^ORCID,Kejík Zdeněk¹²³^ORCID,Kaplánek Robert²⁵^ORCID,Dytrych Petr⁶,Sinica Alla¹²,Vozniuk Oleksandra¹,Martásek Pavel³,Jakubek Milan¹²³^ORCID

Affiliation:

1. Department of Analytical Chemistry, Faculty of Chemical Engineering, University of Chemistry and Technology, Technická 6, 166 28 Prague, Czech Republic

2. BIOCEV, Biotechnology and Biomedicine Center of the Academy of Sciences and Charles University in Vestec, Průmyslová 595, 252 50 Vestec, Czech Republic

3. Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 455/2, 128 08 Prague, Czech Republic

4. Department of Immunology and Microbiology, First Faculty of Medicine, Charles University, Studničkova 7, 128 00 Prague, Czech Republic

5. Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Technická 6, 166 28 Prague, Czech Republic

6. Department of Surgery-Department of Abdominal, Thoracic Surgery and Traumatology, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 2, 121 08 Prague, Czech Republic

Abstract

SARS-CoV-2 is a serious viral pathogen, and agents that inhibit its replication are in high demand. In the present work, we prepared two novel tryptanthrin derivates bearing a thiosemicarbazone moiety as potential antiviral agents. Both compounds displayed potent chelation activity against Fe(III/II) ion-associated COVID-19. The molecular docking results suggest that the compounds can display significant affinity towards SARS-CoV-2 papain-like proteases and SARS-CoV-2 main proteases. In addition, administering T8H-TSC can repress viral replication in the used model (Vero cells). Moreover, the therapeutic potential of the prepared compounds was predicted and analysed in terms of Lipinski’s rules, drug-likeness and drug score.

Funder

Charles University

Ministry of Education, Youth, and Sports of Czech Republic

Technology Agency of the Czech Republic

Operational Programme Research, Development, and Education

Ministry of Health

European Union—Next Generation EU

Publisher

MDPI AG

Subject

Filtration and Separation,Analytical Chemistry

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