Purification of Carrier-Free 47Sc of Biomedical Interest: Selective Separation Study from natCa(n,γ)

Abstract

47Sc for theranostic medical applications was produced from the neutron activation of a natural calcium target. Liquid–liquid extraction for separation of the 47Sc radioisotope from 47Ca was carried out with the extractant Cyanex 272 ((2,4,4-trimethylpentyl) phosphinic acid). The effects of various extraction parameters on the extraction efficiency and separation of the two radionuclides were investigated, including the extraction time, pH, metal ion concentrations, extractant concentration, diluent type, and phase ratio. It was shown that the extraction yield of the 47Sc radioisotope with the proposed procedure is about 90%, with a fast separation time of 10 min, at pH 1.8 (0.01 M HCl), and with low E (1%) for 47Ca and high separation factors. The stripping % of the loaded 47Sc isotope was about 99.2% using 0.4 M oxalic acid solution with a purity of 99.9%.