Physical Exercise Decreases Endoplasmic Reticulum Stress in Central and Peripheral Tissues of Rodents: A Systematic Review

Author:

de Sousa Fernandes Matheus Santos1,Badicu Georgian2ORCID,Santos Gabriela Carvalho Jurema3ORCID,Filgueira Tayrine Ordonio4,Henrique Rafael dos Santos5,de Souza Raphael Fabrício6ORCID,Aidar Felipe J.6ORCID,Souto Fabrício Oliveira4,Brum Patrícia Chakur7ORCID,Lagranha Claudia Jacques1

Affiliation:

1. Graduate Program in Neuropsychiatry and Behavioral Sciences, Center for Medical Sciences, Federal University of Pernambuco, Recife 507400-600, Pernambuco, Brazil

2. Department of Physical Education and Special Motricity, Transilvania University of Brasov, 500068 Brasov, Romania

3. Postgraduate Program in Nutrition, Federal University of Pernambuco, Recife 507400-600, Pernambuco, Brazil

4. Graduate Program in Applied Health Biology, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife 507400-600, Pernambuco, Brazil

5. Department of Physical Education, Federal University of Pernambuco, Recife 507400-600, Pernambuco, Brazil

6. Department of Physical Education, Federal University of Sergipe, São Cristovão 49100-000, Sergipe, Brazil

7. School of Physical Education and Sport, Universidade de São Paulo, São Paulo 05508-900, São Paulo, Brazil

Abstract

Endoplasmic reticulum stress (ER stress) affects many tissues and contributes to the development and severity of chronic diseases. In contrast, regular physical exercise (PE) has been considered a powerful tool to prevent and control several chronic diseases. The present systematic review aimed to evaluate the impact of different PE protocols on ER stress markers in central and peripheral tissues in rodents. The eligibility criteria were based on PICOS (population: rodents; intervention: physical exercise/physical training; control: animals that did not undergo training; outcomes: endoplasmic reticulum stress; studies: experimental). The PubMed/Medline, Science Direct, Scopus, and Scielo databases were analyzed systematically. Quality assessment was performed using SYRCLE’s risk of bias tool for animal studies. The results were qualitatively synthesized. Initially, we obtained a total of 2.490 articles. After excluding duplicates, 30 studies were considered eligible. Sixteen studies were excluded for not meeting the eligibility criteria. Therefore, 14 articles were included. The PE protocol showed decreased levels/expression of markers of ER stress in the central and peripheral tissues of rodents. PE can decrease ER stress by reducing cellular stress in the cardiac, brain, and skeletal muscle tissues in rodents. However, robust PE protocols must be considered, including frequency, duration, and intensity, to optimize the PE benefits of counteracting ER stress and its associated conditions.

Publisher

MDPI AG

Subject

Applied Psychology,Clinical Psychology,Developmental and Educational Psychology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Chronic diseases: Origin and cell mechanisms involved;Cellular and Molecular Biology;2023-12-31

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