Abstract
Spinal cord injury (SCI) results in neural tissue loss and so far untreatable functional impairment. In addition, at the initial injury site, inflammation induces secondary damage, and glial scar formation occurs to limit inflammation-mediated tissue damage. Consequently, it obstructs neural regeneration. Many studies have been conducted in the field of SCI; however, no satisfactory treatment has been established to date. Hepatocyte growth factor (HGF) is one of the neurotrophic growth factors and has been listed as a candidate medicine for SCI treatment. The highlighted effects of HGF on neural regeneration are associated with its anti-inflammatory and anti-fibrotic activities. Moreover, HGF exerts positive effects on transplanted stem cell differentiation into neurons. This paper reviews the mechanisms underlying the therapeutic effects of HGF in SCI recovery, and introduces recent advances in the clinical applications of HGF therapy.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference55 articles.
1. A review and update on the guidelines for the acute non-operative management of cervical spinal cord injury;Readdy;J. Neurosurg. Sci.,2015
2. A review and update on the current and emerging clinical trials for the acute management of cervical spine and spinal cord injuries—Part III;Yue;J. Neurosurg. Sci.,2016
3. Role of myelin-associated inhibitors in axonal repair after spinal cord injury
4. Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats
5. Partial characterization of a hepatocyte growth factor from rat platelets
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