An Unsupervised Classifier for Whole-Genome Phylogenies, the Maxwell© Tool

Author:

Gardes Joël1,Maldivi Christophe1,Boisset Denis1,Aubourg Timothée2,Demongeot Jacques2ORCID

Affiliation:

1. Orange Labs, 38229 Meylan, France

2. Faculty of Medicine, Université Grenoble Alpes, AGEIS EA 7407 Tools for e-Gnosis Medical, 38700 La Tronche, France

Abstract

The development of phylogenetic trees based on RNA or DNA sequences generally requires a precise and limited choice of important RNAs, e.g., messenger RNAs of essential proteins or ribosomal RNAs (like 16S), but rarely complete genomes, making it possible to explain evolution and speciation. In this article, we propose revisiting a classic phylogeny of archaea from only the information on the succession of nucleotides of their entire genome. For this purpose, we use a new tool, the unsupervised classifier Maxwell, whose principle lies in the Burrows–Wheeler compression transform, and we show its efficiency in clustering whole archaeal genomes.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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