The Protective Effects of Reineckia carnea Ether Fraction against Alzheimer’s Disease Pathology: An Exploration in Caenorhabditis elegans Models

Author:

Fu Hai-Jun12,Zhou Xing-Yue12,Li Ya-Ping12,Chen Xue12,He Yan-Ni12,Qin Da-Lian1,Yu Lu1,Yu Chong-Lin1,Wu Jian-Ming1ORCID,Wu An-Guo1ORCID,Zhou Xiao-Gang12ORCID

Affiliation:

1. Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, School of Pharmacy, Southwest Medical University, Luzhou 646000, China

2. Central Nervous System Drug Key Laboratory of Sichuan Province, Luzhou 646000, China

Abstract

Alzheimer’s disease (AD) presents a significant challenge to global healthcare systems, with current treatments offering only modest relief and often bringing unwanted side effects, necessitating the exploration of more effective and safer drugs. In this study, we employed the Caenorhabditis elegans (C. elegans) model, specifically the AD-like CL4176 strain expressing the human Aβ(1–42) protein, to investigate the potential of Reineckia carnea extract and its fractions. Our results showed that the Reineckia carnea ether fraction (REF) notably diminished the paralysis rates of CL4176 worms. Additionally, REF also attenuated the neurotoxicity effects prompted by Tau proteins in the BR5270 worms. Moreover, REF was observed to counteract the accumulation of Aβ and pTau proteins and their induced oxidative stress in C. elegans AD-like models. Mechanistic studies revealed that REF’s benefits were associated with the induction of autophagy in worms; however, these protective effects were nullified when autophagy-related genes were suppressed using RNAi bacteria. Together, these findings highlight Reineckia carnea ether fraction as a promising candidate for AD treatment, warranting further investigation into its autophagy-inducing components and their molecular mechanisms.

Funder

National Natural Science Foundation of China

Science and Technology Planning Project of Sichuan Province

Luzhou Municipal People’s Government and Southwest Medical University

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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