Topical Cellular/Tissue and Molecular Aspects Regarding Nonpharmacological Interventions in Alzheimer’s Disease—A Systematic Review

Author:

Aurelian Sorina12ORCID,Ciobanu Adela13ORCID,Cărare Roxana4,Stoica Simona-Isabelle56,Anghelescu Aurelian56ORCID,Ciobanu Vlad7,Onose Gelu15ORCID,Munteanu Constantin58ORCID,Popescu Cristina15,Andone Ioana15,Spînu Aura15,Firan Carmen9,Cazacu Ioana Simona5,Trandafir Andreea-Iulia15ORCID,Băilă Mihai15,Postoiu Ruxandra-Luciana15,Zamfirescu Andreea12ORCID

Affiliation:

1. Faculty of Medicine, University of Medicine and Pharmacy “Carol Davila”, 020022 Bucharest, Romania

2. Gerontology and Geriatrics Clinic Division, St. Luca Hospital for Chronic Illnesses, 041915 Bucharest, Romania

3. Department of Psychiatry, ‘Prof. Dr. Alexandru Obregia’ Clinical Hospital of Psychiatry, 041914 Bucharest, Romania

4. Faculty of Medicine, University of Southampton, Southampton SO16 7NS, UK

5. NeuroRehabilitation Clinic Division, Teaching Emergency Hospital “Bagdasar-Arseni”, 041915 Bucharest, Romania

6. Faculty of Midwifery and Nursing, University of Medicine and Pharmacy “Carol Davila”, 020022 Bucharest, Romania

7. Computer Science Department, Politehnica University of Bucharest, 060042 Bucharest, Romania

8. Faculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iași, Romania

9. NeuroRehabilitation Compartment, The Physical and Rehabilitation Medicine & Balneology Clinic Division, Teaching Emergency Hospital of the Ilfov County, 022104 Bucharest, Romania

Abstract

One of the most complex and challenging developments at the beginning of the third millennium is the alarming increase in demographic aging, mainly—but not exclusively—affecting developed countries. This reality results in one of the harsh medical, social, and economic consequences: the continuously increasing number of people with dementia, including Alzheimer’s disease (AD), which accounts for up to 80% of all such types of pathology. Its large and progressive disabling potential, which eventually leads to death, therefore represents an important public health matter, especially because there is no known cure for this disease. Consequently, periodic reappraisals of different therapeutic possibilities are necessary. For this purpose, we conducted this systematic literature review investigating nonpharmacological interventions for AD, including their currently known cellular and molecular action bases. This endeavor was based on the PRISMA method, by which we selected 116 eligible articles published during the last year. Because of the unfortunate lack of effective treatments for AD, it is necessary to enhance efforts toward identifying and improving various therapeutic and rehabilitative approaches, as well as related prophylactic measures.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Reference205 articles.

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2. United Nations Department of Economic and Social Affairs, Population Division (2020). World Population Ageing 2020 Highlights: Living Arrangements of Older Persons (ST/ESA/SER.A/451), Economic and Social Affairs United Nations. Available online: https://digitallibrary.un.org/record/3898412.

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5. Behavioral and Psychological Symptoms of Dementia in Different Dementia Disorders: A Large-Scale Study of 10,000 Individuals;Schwertner;J. Alzheimer’s Dis.,2022

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