Microwave and Radiofrequency Ablation: A Comparative Study between Technologies in Ex Vivo Tissues

Author:

Lobascio Fabio1,Di Modugno Rocco1,Fiore Marco1,Di Modugno Nicola1,Bruno Cristian1,De Nicolo Thomas1,Barberis Rossella Veronica2,Cabiale Karine2ORCID,Radoiu Marilena3ORCID

Affiliation:

1. Leanfa s.r.l., Via C. A. Dalla Chiesa 6, 70037 Ruvo di Puglia, Italy

2. Life and Devices s.r.l., Via G. Quarello 15, 10135 Torino, Italy

3. Microwave Technologies Consulting, 69140 Lyon, France

Abstract

In this paper, we report on the use of a purpose-built hybrid solid-state microwave and radiofrequency generator operating at frequencies of 2.45 GHz and/or 480 kHz for cancer ablation in various tissues. The hybrid generator was tested ex vivo on chicken breast and bovine liver and has demonstrated that the high accuracy of the power delivered to the sample can be achieved by controlling the emitted power versus the temperature profile of the treated sample. In particular, the hybrid generator incorporates control systems based on impedance or reflected power measurements that allow controlled ablation without causing unwanted carbonization and without including areas where tissue damage is not desired. The results of the ex vivo tests showed that radiofrequency ablation (RFA) could be effective for performing controlled ablations with minimally invasive probes, such as cardiac pathologies, small lesions, and tissues with particular composition, while microwave ablation (MWA) could be optimal for performing large ablations in highly vascularized tissues, such as liver cancer, where it is necessary to achieve higher temperatures.

Publisher

MDPI AG

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