Rapid Environmental Impact Assessment of Penicillin G in a Veterinary Product Using an Original Software Method and Monitoring by SPE-Online-UHPLC-MS/MS-Reference-Cited by-同舟云学术

Rapid Environmental Impact Assessment of Penicillin G in a Veterinary Product Using an Original Software Method and Monitoring by SPE-Online-UHPLC-MS/MS

Published:2023-08-24 Issue:17 Volume:28 Page:6227
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Ciucă Viviana Carmen¹,Safta Victor Viorel¹,Rusănescu Carmen Otilia¹^ORCID,Paraschiv Gigel¹,Deák György²,Ilie Mihaela²,Cănănău Sorin³^ORCID

Affiliation:

1. Faculty of Biotechnical Systems Engineering, University of Science and Technology Politehnica Bucharest, 313 Spl. Independentei, 060042 Bucharest, Romania

2. National Institute for Research and Development in Environmental Protection, 294 Spl. Independentei, District 6, 060031 Bucharest, Romania

3. Faculty of Mechanical and Mechatronic Engineering, University of Science and Technology Politehnica Bucharest, 313 Spl. Independentei, 060042 Bucharest, Romania

Abstract

Veterinary antibiotics have become a major concern due to potential environmental effects. This study presents an investigation of the exposure and environmental effects of the veterinary medicinal product in powder form, administered in the drinking water of piglets, chickens and turkeys, containing 250 mg/g penicillin G (benzylpenicillin potassium), performed according to the European Medicines Agency (EMEA) guideline and the results obtained by an analytical method based on online solid-phase extraction, ultra-high performance liquid chromatography coupled to a triple quadrupole mass spectrometer (SPE-online-UHPLC-MS/MS). The study presents the determination of the environmental risk and through an original, interactive, fast software method, created on the basis of a proprietary calculation algorithm that goes through all the prescriptions and recommendations of the EMEA guide. The results demonstrated that the concentration value for penicillin G determined in surface water by SPE-online-UHPLC-MS/MS is much lower than that predicted by calculation (predictable concentration in surface water, PECsurface water = 37.66 µg/L and the concentration SPE-online-UHPLC-MS/MS = 0.032 µg/L). Both results lead to a sub-unit risk quotient (R) indicating that the treatment carried out with the considered veterinary product does not present any risk to the environment.

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/17/6227/pdf

Reference46 articles.

1. Environmental Impacts of Antibiotic Use in the Animal Production Industry, Prevention of Infectious Diseases in Livestock and Wildlife;Krapac;Ecol. Anim.,2012

2. Determination of persistent tetracycline residues in soil fertilized with liquid manure by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry;Hamscher;Anal. Chem.,2002

3. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999–2000: A national reconnaissance;Kolpin;Environ. Sci. Technol.,2002

4. Environmental consequences of treating cattle with the antiparasitic drug ivermectin;Wall;Nature,1987

5. Halling-Sørensen, B., Nielsen, S.N., and Jensen, J. (2002). Environmental Assessment of Veterinary Medicines in Denmark, Danish Environmental Protection Agency.