Chemical Constituents and Bioactivities of the Plant-Derived Fungus Aspergillus fumigatus-Reference-Cited by-同舟云学术

Chemical Constituents and Bioactivities of the Plant-Derived Fungus Aspergillus fumigatus

Published:2024-01-30 Issue:3 Volume:29 Page:649
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Sang Zihuan¹²³,Zhang Yanjiang³,Qiu Kaidi³,Zheng Yuting¹,Chen Chen¹²³,Xu Li¹,Lai Jiaying³,Zou Zhenxing¹,Tan Haibo¹²³

Affiliation:

1. Hunan Key Laboratory of Diagnostic and Therapeutic Drug Rsearch for Chronic Diseases, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China

2. National Engineering Research Center of Navel Orange, Gannan Normal University, Ganzhou 341000, China

3. Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China

Abstract

A new bergamotane sesquiterpenoid, named xylariterpenoid H (1), along with fourteen known compounds (2–15), were isolated from the crude extract of Aspergillus fumigatus, an endophytic fungus isolated from Delphinium grandiflorum L. Their structures were elucidated mainly by extensive analyses of NMR and MS spectroscopic data. In addition, the screening results of antibacterial and cytotoxic activities of compounds 1–15 showed that compound 4 displayed antibacterial activities against Staphylococcus aureus and MRSA (methicillin-resistant S. aureus) with an MIC value of 3.12 µg/mL.

Funder

South China Botanical Garden, Chinese Academy of Sciences

Key Research and Development Project of Hainan Province

Natural Science Foundation of Hunan Province

Youth Innovation Promotion Association of CAS

National Natural Science Foundation of China

Open Sharing Fund for the Large-Scale Instruments and Equipment of Central South University

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/29/3/649/pdf

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