Chemical Studies of Multicomponent Kidney Stones Using the Modern Advanced Research Methods

Author:

Sofińska-Chmiel Weronika1,Goliszek Marta1ORCID,Drewniak Marek1,Nowicka Aldona1,Kuśmierz Marcin1,Adamczuk Agnieszka2ORCID,Malinowska Paulina1,Maciejewski Ryszard34,Tatarczak-Michalewska Małgorzata5ORCID,Blicharska Eliza5

Affiliation:

1. Analytical Laboratory, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie Skłodowska University, Maria Curie Skłodowska Sq. 2, 20-031 Lublin, Poland

2. Institute of Agrophysics Polish Academy of Sciences, Doświadczalna 4 Str., 20-290 Lublin, Poland

3. Department of Anatomy, Medical University of Lublin, Jaczewskiego 4 Str., 20-090 Lublin, Poland

4. Institute of Health Sciences, The John Paul II Catholic University of Lublin, Kostantynów 1 H Str., 20-708 Lublin, Poland

5. Department of Pathobiochemistry and Interdisciplinary Applications of Ion Chromatography, Medical University of Lublin, 1 Chodźki Str., 20-093 Lublin, Poland

Abstract

Defining the kidney stone composition is important for determining a treatment plan, understanding etiology and preventing recurrence of nephrolithiasis, which is considered as a common, civilization disease and a serious worldwide medical problem. The aim of this study was to investigate the morphology and chemical composition of multicomponent kidney stones. The identification methods such as infrared spectroscopy (FTIR), X-ray diffraction (XRD), and electron microscopy with the EDX detector were presented. The studies by the X-ray photoelectron spectroscopy (XPS) were also carried out for better understanding of their chemical structure. The chemical mapping by the FTIR microscopy was performed to show the distribution of individual chemical compounds that constitute the building blocks of kidney stones. The use of modern research methods with a particular emphasis on the spectroscopic methods allowed for a thorough examination of the subject of nephrolithiasis.

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Reference48 articles.

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