Abstract
Deep learning methods for RNA secondary structure prediction have shown higher performance than traditional methods, but there is still much room to improve. It is known that the lengths of RNAs are very different, as are their secondary structures. However, the current deep learning methods all use length-independent models, so it is difficult for these models to learn very different secondary structures. Here, we propose a length-dependent model that is obtained by further training the length-independent model for different length ranges of RNAs through transfer learning. 2dRNA, a coupled deep learning neural network for RNA secondary structure prediction, is used to do this. Benchmarking shows that the length-dependent model performs better than the usual length-independent model.
Funder
National Natural Science Foundation of China
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Cited by
9 articles.
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