Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets-Reference-Cited by-同舟云学术

Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets

Published:2024-03-20 Issue:6 Volume:29 Page:1373
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Talib Wamidh H.¹^ORCID,Awajan Dima²^ORCID,Alqudah Abdelrahim³^ORCID,Alsawwaf Razan²,Althunibat Raha²^ORCID,Abu AlRoos Mahmoud²^ORCID,Al Safadi Ala’a²,Abu Asab Sharif²,Hadi Rawan W.¹,Al Kury Lina T.⁴^ORCID

Affiliation:

1. Faculty of Allied Medical Sciences, Applied Science Private University, Amman 11931, Jordan

2. Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931, Jordan

3. Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa 13133, Jordan

4. Department of Health Sciences, College of Natural and Health Sciences, Zayed University, Abu Dhabi 144534, United Arab Emirates

Abstract

Epigallocatechin gallate (EGCG) is a catechin, which is a type of flavonoid found in high concentrations in green tea. EGCG has been studied extensively for its potential health benefits, particularly in cancer. EGCG has been found to exhibit anti-proliferative, anti-angiogenic, and pro-apoptotic effects in numerous cancer cell lines and animal models. EGCG has demonstrated the ability to interrupt various signaling pathways associated with cellular proliferation and division in different cancer types. EGCG anticancer activity is mediated by interfering with various cancer hallmarks. This article summarize and highlight the effects of EGCG on cancer hallmarks and focused on the impacts of EGCG on these cancer-related hallmarks. The studies discussed in this review enrich the understanding of EGCG’s potential as a therapeutic tool against cancer, offering a substantial foundation for scientists and medical experts to advance scientific and clinical investigations regarding EGCG’s possibility as a potential anticancer treatment.

Funder

Applied Science Private University, Amman, Jordan

Publisher

MDPI AG

Link

https://www.mdpi.com/1420-3049/29/6/1373/pdf

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